Description
Materials with high surface-to-volume ratios demonstrate exquisite sensitivity and detection limits in diverse sensing applications. Integration of nanowires, nanotubes, and two-dimensional (2D) semiconductors into sensing devices, however, presents challenges inhibiting the development of products based on these materials.
To realize applications of 2D transducers in ubiquitous low-cost diagnostic devices, new fabrication approaches are required. Processes for high-rate (>106 per day) mass production of low-cost two-dimensional electronic medical diagnostic devices with limits of detection rivaling PCR will be presented. Processing methods allow for control of binding site density and adjustable dynamic range of sensor devices. Response times for most analytes are 2 minutes or less, and detection of multiple analytes on an array of sensors fabricated on a single flexible chip is straightforward.
A large supply of unfunctionalized diagnostic devices manufactured in this way may be stored to be functionalized with any selective binding agent on-demand to immediately reduce the impact of future disease outbreaks. Materials for large-scale device fabrication were selected to ensure the recyclability of the devices for reduced waste stream impact in anticipation of large numbers of devices being consumed daily.
Contributors
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Prof. Dr. Christopher Muratore
Ohio Research Scholars Endowed Chair Professor in the Chemical and Materials Engineering Department at the University of Dayton. Christopher was an American Society of Engineering Education Post-Doctoral Fellow at the US Naval Research Lab Plasma Physics Division (2002-2004), spent 10 years as a staff scientist at the Air Force Research Laboratory, and joined the University of Dayton in 2012. He still works closely with many groups at AFRL focusing on sensor development and flexible electronics. Throughout his 22 year research career, Christopher’s work has focused on engineering surfaces and interfaces for applications including chemical and biological sensors. He has published over 100 peer-reviewed articles and has over 11 patents granted or pending. He is a Fellow of the American Vacuum Society.