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MDS/MPN Overlap Disorders: The Challenges of Diagnosing and Treating

Release date: December 2017
Expiration date:December 2019

Estimated time to complete activity: 1.0 hours

This activity is jointly provided by Medical Education Resources and the Aplastic Anemia and MDS International Foundation

This activity is supported by an educational grant from Celgene.

Target Audience

This activity has been designed to meet the educational needs of hematologists/oncologists, pathologists, physician assistants, nurse practitioners involved in the care of patients with MDS/MPN Overlap Disorders.

Program Overview

Practitioners participating in this program will be able to select the most appropriate and efficacious treatment for patients with MDS/MPN from this in-depth review and analysis of recent research on the impact of molecular mutations, updated diagnostic tools, and new therapeutic options to improve outcomes.

Educational Objectives

After completing this activity, the participant should be better able to:
  • Design a management strategy based on clinical presentations and diagnostic workup of MDS and MPN
  • Utilize appropriate diagnostic testing in the workup of patients with MDS and MPN
  • Utilize tools for risk assessment and stratification in this patient population
  • Treat patients with available therapeutic agents, including combination therapies and those in clinical trials.


David Steensma, MD
Attending Physician, Hematologic Oncology, Dana-Farber Cancer Institute
Attending Physician, Medicine, Brigham And Women's Hospital
Associate Professor, Medicine, Harvard Medical School

Katherine Edmonds, ARNP
Adult Leukemia Program, Dana-Farber Cancer Institute

Robert Hasserjian, MD
Associate Pathologist, Massachusetts General Hospital
Associate Professor of Pathology, Harvard Medical School

Program Agenda

Case studies are used throughout the program to illustrate the challenges of diagnosing and treating MDS/MPN Overlap Disorders. Topics include:
  • Atypical CML
  • MDS/MPN 2016 WHO classification
  • Key features of MDS/MPN
  • CMML
  • MDS/MPN/MF Diagnostic Spectrum Reference

Physician Credit

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Education Resources (MER) and the Aplastic Anemia and MDS International Foundation (AAMDSIF). MER is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation

Medical Education Resources designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Conflicts of Interest

Medical Education Resources ensures balance, independence, objectivity, and scientific rigor in all our educational programs. In accordance with this policy, MER identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by MER to ensure that all scientific research referred to, reported, or used in a continuing education activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing its learners with high-quality activities that promote improvements or quality in health care and not the business interest of a commercial interest.

The faculty reported the following financial relationships with commercial interests whose products or services may be mentioned in this activity:

Name of Faculty Reported Financial Relationship
David Steensma, MDConsulting – Amgen, Janssen, Onconova
Ownership Interest/Shareholder – Acceleron, Incyte
Katherine Edmonds, ARNPNo financial relationships to disclose
Robert Hasserjian, MDConsulting – Celgene, Promedior

The content managers reported the following financial relationships with commercial interests whose products or services may be mentioned in this activity:

Name of Content ManagerReported Financial Relationship
Alice HoukNo financial relationships to disclose
Veronda Smith, FNP-BCNo financial relationships to disclose

Method of Participation

There are no fees for participating in and receiving credit for this activity. During the period December 2017 through December 2019, participants must 1) read the learning objectives and faculty disclosures, 2) study the educational activity, 3) complete the posttest by recording the best answer to each question in the answer key on the evaluation form, 4) complete the evaluation form, and 5) complete the evaluation form.

A statement of credit will be issued only upon a completed activity evaluation form and a completed posttest with a score of 75% or better.


The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of Medical Education Resources, the Aplastic Anemia and MDS International Foundation, and/or Celgene. The authors have disclosed if there is any discussion of published and/or investigational uses of agents that are not indicated by the FDA in their presentations. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Medical Education Resources, the Aplastic Anemia and MDS International Foundation, and/or Celgene. Before prescribing any medicine, primary references and full prescribing information should be consulted. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. The information presented in this activity is not meant to serve as a guideline for patient management.

Nursing Credit
Medical Education Resources is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

This CE activity provides 1.0 contact hours of continuing nursing education.

Medical Education Resources is a provider of continuing nursing education by the California Board of Registered Nursing, Provider #CEP 12299, for 1.0 contact hours.

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