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What’s New in Aplastic Anemia and PNH? Important Findings from ASH 2018

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Contributors

  • Bhumika Patel, MD

    After securing the Edward P. Evan’s Foundation MDS fellowship position in the Department of Translational Hematologic Oncology Research from 2014-16, Dr. Patel completed a hematology/oncology fellowship at Cleveland Clinic from 2015-2018. Her research has focused on clinical application of various genomic sequencing techniques to explore the clonal complexities of myeloid malignancies and bone marrow failure conditions. Specifically, she clarified the complex interactions among chromosomal abnormalities and point mutations and identified ancestral/founder events to recapitulate the clonal hierarchy of the mutations. These results have helped uncover the molecular underpinnings of the clinical heterogeneity of the myeloid neoplasia, while identification of ancestral molecular events have helped identify targetable mutations, and have made prognostication more accurate. Dr. Patel’s goals are now to apply this understanding of molecular biology of myeloid neoplasia and to clarify the best application of current available therapies.

  • Jaroslaw Maciejewski, MD, PhD

    Dr. Maciejewski attended medical school at the Medical School Charite, Humboldt University in Berlin, Germany receiving both his medical degree and doctorate from the Institute for Medical Immunology at Humboldt University Medical School. He completed his internal medicine residency at the University of Nevada, School of Medicine in Reno, NV and Hematology Fellowship at the National Institutes of Health Medical Center in Bethesda, MD. He also completed his postdoctoral research fellowship at the Hematology Branch of the National Heart, Lung and Blood Institute (NHLBI) in Bethesda, MD where he later served as Staff Scientist before joining the Cleveland Clinic in 2001 as a Staff Physician and Section Head of Experimental Hematology. In January 2009, Dr. Maciejewski was appointed Chairman of the Department of Translational Hematology & Oncology Research at the Taussig Cancer Institute within the Cleveland Clinic. Dr. Maciejewski has been a long-term member of the American Society of Hematology (ASH) and his research was chosen for presentation during the Plenary Session of the annual ASH Meeting in both 2010 and 2012. He has published over 150 articles as first or senior author, including papers in Nature Genetics, Blood, and Cancer Cell. 

    His clinical areas of expertise include bone marrow failure syndromes (including aplastic anemia, myelodysplastic syndrome, large granular lymphocyte leukemia, paroxysmal nocturnal hemoglobinuria), and myeloid malignancies. His research deals with the molecular pathogenesis of these disorders and deals with various specific aspects of stem cell biology, genetics, cytogenetics and immunobiology. He has developed multiple whole genome scanning technologies for laboratory.

March 4, 2019
Mon 2:00 PM EST

Duration 1H 0M

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