This session was originally presented by Patrice A. Harris, MD MA, and Kurt Kroenke, MD, during the AAPM 34th Annual Meeting in April 2018. It provides an update on the Centers for Disease Control and Prevention (CDC) guideline and opioid-related regulatory issues in 2018, as well as their impact on both patients in pain and their treating physicians. Speakers provide their points of view followed by an interactive session with the goal of improving attendee and speaker perspectives on the intended, and unintended, consequences of the CDC guidelines and resultant regulations.