This course provides a detailed overview on key concepts in transporter pharmacology that are essential for academic, industrial, and regulatory pharmaceutical scientists.Transporters are critical determinants of both tissue drug disposition and drug efficacy. Over the past several years, multiple uptake and efflux transporters have been identified and characterized. Advances in molecular pharmacology have shown that transport systems are extremely dynamic and can be modulated by disease and by drugs themselves. Furthermore, genetic differences in transporters can contribute to vastly different pharmacokinetic and/or pharmacodynamics profiles within human populations. In addition to their involvement in drug disposition, transporters can also contribute to clinically significant drug-drug interactions.
- Provide an overview of transporters and their role in determining PK/PD properties of drugs.
- Outline state-of-the-art in vitro, in silico, and in vivo approaches for the study of drug transport mechanisms and discuss the advantages and disadvantages of each methodology.
- Highlight involvement of transporters in drug disposition into key organs such as intestine, liver, kidney, and brain as well as other organs and tissues (i.e., eye, lung, skin, male/female genital tract, endocrine glands).
- Provide detailed information on regulation of transporters in response to pathophysiological and pharmacological stressors.
- Review key concepts on the interplay of transporters and drug metabolizing enzymes.
- Highlight the role of transporters in clinically significant drug-drug interactions.
- Provide an overview of key concepts in the pharmacogenomics of transporters.
- Discuss the integration of drug transport data into the drug development process.
- Highlight the current FDA guidance on the study of transporters in the drug discovery and drug development process.
Continuing Education Credit for PharmacistsPharmacists can receive 18.5 hours of continuing education credit for completing this eCourse.
The Division of Pharmacy Professional Development at the University of Wisconsin-Madison School of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This program has been approved for 18.5 hours (1.85 CEUs) of pharmacy continuing education credit. Credit is based on documented program completion of the course materials and an electronic version of the Program Evaluation/Post-Assessment with electronic submission of credit information to the National Association of Boards of Pharmacy.
Universal program number: 0073-9999-17-501-H04-P
Release date: 01-31-2016
Expiration date: 1-31-2019