This presentation will focus on advantage of nasal powder formulations and non-human primate (NHP) model to quantify nose to brain delivery of a model compound. This presentation will compare pharmacokinetic advantages of nasal powder formulations to aqueous formulations. Formulation and invitro performance attributes for delivery of nasal powders will be discussed.

The results from an NHP crossover study performed in cynomologus macaques will be presented. The study focused on systemic and cerebral spinal fluid (CSF) drug concentrations of sumatriptan administered nasally by a dry powder device, a liquid aerosol delivery and subcutaneous delivery. A model was successfully developed to quantify CSF delivery with data that suggests that the NHP model can be used to evaluate nasal delivery as a non-clinical model. In addition, the model differentiated systemic and CSF drug concentrations across the three device platforms.

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