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  1. Courses
  2. Preformulation 101

Preformulation 101

Welcome

Upon completion of the lectures, participants will have a high-level understanding of the role of preformulation in formulation development and gain familiarity with the main tasks performed in preformulation space:
  • Drug substance
    • Selection of appropriate physical form of the drug substance and material properties.
    • Determination of physico-chemical and biopharmaceutical properties e.g. pKa, LogD, MP, Tg, solubility and dissolution in pharmaceutical and biorelevent solvents, permeability, chemical and physical stability, and mechanism of degradation.
  • Drug product
    • Excipient compatibility studies including physicomechanical impact on stability, prototype formulations, bioperformance evaluation, bioavailability enhancement through solubilization approaches, and on-site formulation development.

Course Objectives

A fundamental role of formulation scientists is to convert candidate drugs into drug products. To achieve this goal, it is important to have a thorough understanding of a drug’s pharmaceutical properties. The objective of this course is to provide fundamentals of the preformulation studies and how the physicochemical, physicomechanical, and biopharmaceutical properties data generated during these studies can impact:
  1. Candidate selection;
  2. Formulation design;
  3. Choice of drug delivery technology;
  4. Drug product manufacturing process;
  5. Pharmacokinetic/biopharmaceutical properties of the resulting product;
  6. Stability of the drug substance and drug product;
  7. Choice of the analytical techniques; and
  8. Packaging of the product.

Upon completion of this eCourse, the participant will understand the role of preformulation in formulation development and gain familiarity with the main tasks performed in preformulation space and should be able to:
  • Select the appropriate physical form of the drug substance and material properties and determination of physico-chemical and biopharmaceutical properties (e.g. pKa, LogD, MP, Tg, solubility and dissolution in pharmaceutical and biorelevent solvents, permeability, chemical and physical stability, and mechanism of degradation) for a given drug substance and drug product
  • Evaluate excipient compatibility studies including physicomechanical impact on stability, prototype formulations, bioperformance evaluation, bioavailability enhancement through solubilization approaches, on-site formulation development for a given drug product
AAPS members, students, and academicians enjoy special pricing. Previews of each of the lectures are available. Participants have access to the course content for a 6 month period following purchase. 

Purchase Now
Purchase the entire course—all 10 lectures—at an even greater discount by clicking the button below. Interested in just a lecture or two? Scroll down to add lectures to your cart individually. 

 ($469.00-$889.00)

$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 1: Preformulation Considerations in Drug Product Design

Presentation: Ronald Smith, Ph.D., 47 min 42 sec

Assessment- Lecture 1

Assessment: 7 questions 5 retakes

Evaluation - Lecture 1

Survey: 13 questions

Preformulation Considerations in Drug Product Design

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 2: Drug Substance Physical Form Selection

Presentation: Balvinder Vig, Ph.D. , 52 min 38 sec

Assessment- Lecture 2

Assessment: 8 questions 5 retakes

Evaluation - Lecture 2

Survey: 13 questions

Drug Substance Physical Form Selection

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 3: Drug Substance Physical Form Characterization

Presentation: Ann Newman, Ph.D., 71 min 57 sec

Assessment- Lecture 3

Assessment: 7 questions 5 retakes

Evaluation - Lecture 3

Survey: 13 questions

Drug Substance Physical Form Characterization

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 4: Solubility: General Principles and Practical Considerations

Presentation: Rodolfo Pinal, Ph.D. , 75 min 38 sec

Assessment- Lecture 4

Assessment: 9 questions 5 retakes

Evaluation - Lecture 4

Survey: 13 questions

Solubility: General Principles and Practical Considerations

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 5: Dissolution and its Role in Solid Oral Dosage Form Development

Presentation: Greg Amidon, Ph.D. , 61 min 9 sec

Assessment- Lecture 5

Assessment: 8 questions 5 retakes

Evaluation - Lecture 5

Survey: 13 questions

Dissolution and its Role in Solid Oral Dosage Form Development

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 6: Biopharmaceutic Considerations

Presentation: Raimar Loebenberg, Ph.D. , 47 min 33 sec

Assessment- Lecture 6

Assessment: 6 questions 5 retakes

Evaluation - Lecture 6

Survey: 13 questions

Biopharmaceutic Considerations

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 7: Chemical Stability Assessment in Preformulation

Presentation: Darren Reid, Ph.D. , 62 min 23 sec

Assessment- Lecture 7

Assessment: 10 questions 5 retakes

Evaluation - Lecture 7

Survey: 13 questions

Chemical Stability Assessment in Preformulation

Certificate: 0/3 Course items completed
$59.00 - $129.00
Member
$109.00
Non-Member
$129.00
Student
$59.00
E-Subscriber
$129.00

Lecture 8: Excipient Compatibility Studies

Presentation: Krishnaswamy Raghavan, Ph.D. , 59 min 0 sec

Assessment- Lecture 8

Assessment: 7 questions 5 retakes

Evaluation - Lecture 8

Survey: 13 questions

Excipient Compatibility Studies

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 9: Impact of Material Properties on Formulation Development

Presentation: Teresa Carvajal, Ph.D. , 71 min 44 sec

Assessment- Lecture 9

Assessment: 7 questions 5 retakes

Evaluation - Lecture 9

Survey: 13 questions

Impact of Material Properties on Formulation Development

Certificate: 0/3 Course items completed
$59.00 - $129.00
Student
$59.00
E-Subscriber
$129.00
Member
$109.00
Non-Member
$129.00

Lecture 10: Prototype Formulations Screening and Characterization

Presentation: Irina Kazakevich, Ph.D. , 53 min 40 sec

Assessment- Lecture 10

Assessment: 7 questions 5 retakes

Evaluation - Lecture 10

Survey: 13 questions

Prototype Formulations Screening and Characterization

Certificate: 0/3 Course items completed
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