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Dr. Joshua Sharp is a world renowned and internationally recognized expert in Hydroxyl Radical
Protein Footprinting (HRPF). He has over twenty-one peer-reviewed articles and
has presented numerous invited lectures on the subject of biopharmaceutical
HRPF. Along with acting as the
CTO of GenNext, Dr. Sharp is also an Assistant Professor of Pharmacology in the
Department of BioMolecular Sciences. Dr. Sharp received his PhD from a joint
program between Oak Ridge National Laboratory and the University of Tennessee
under the direction of Dr. Robert Hettich in 2003. Dr. Sharp received his
postdoctoral training at the National Institute of Environmental Health
Sciences in the laboratory of Dr. Kenneth Tomer. Following his postdoctoral
experiences, Dr. Sharp took a research faculty position in the Complex
Carbohydrate Research Center in 2007. In 2015 he joined the Department of
BioMolecular Sciences as an Assistant Professor.
Dr. Sharp is active in
the development and application of new mass spectrometry-based technologies for
studying the structure-function relationships of proteins and carbohydrates of
biomedical interest. Current applications focus on the study of interactions
between neutralizing antibodies and the glycoprotein coat of HIV;
characterization of chemokines and the structural factors mediating their
oligomerization and function; and the identification of glycosaminoglycan structures
with potential biomedical applications for a wide variety of fields including
anti-microbial agents, anti-cancer therapies, and anti-inflammatory therapies.
Dr. Sharp has published
widely in the field of biomolecular mass spectrometry, pioneering some of the
early work in the development of hydroxyl radical protein footprinting for
studying protein structure and interactions. He has received funding from the
National Institutes of Health to support his work in developing and applying
new methods to study the structure of proteins, carbohydrates, and the
complexes they form.