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Impurities in mRNA Vaccines - Unwanted Immune System Activation

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Contributors

  • Sergio Linares-Fern├índez , Ph.D.

    Dr. Sergio Linares-Fernández is a young researcher with a strong expertise in vaccines, immunology, and molecular biology. He graduated on Biotechnology at University of Cadiz (Spain) and continued the Master Erasmus Mundus Leading International Vaccinology Education in 5 different European universities and 3 countries (Spain, Belgium, and France). He pursued a PhD at the Tissue Biology and Therapeutic Engineering Laboratory in Lyon (France) titled "Optimizing an mRNA Vaccine platform against HIV-1: from the in vitro transcription design to envelope protein expression" where he optimized the RNA sequence backbone and combined different mRNA purification steps to decrease RNA immunogenicity/ PRR recognition to increase the mRNA translation efficiency in vitro. During his Ph.D. he also worked in the RNA formulation into LNPs and performed the in vivo proof of concept for 6 different HIV vaccine candidates. Recently, Sergio joined a new adventure in the R&D department of Sanofi Pasteur (France) as RNA Automation Expert at the mRNA Center of Excellence.

May 5, 2022
Thu 12:30 PM EDT

Duration 1H 30M

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