Impurities in mRNA Vaccines - Unwanted Immune System Activation

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Description

This webinar will be focused on development of mRNA tools and technology. During the COVID-19 pandemic haunting us the past three years, we have realized how brilliant is the mRNA technology to the biopharmaceutical companies. During this webinar, we will be able to learn more in detail about the types of impurities that may be generated during mRNA synthesis and how we can produce a cleaner mRNA. Sergio Linares (our speaker) has completed his PhD in France and now working at Sanofi Pasteur. He has great expertise in this field and willing to share his knowledge with our scientists working in vaccines, biotechnology, and pharmaceutical field.

Learning Objectives:

Basics of mRNA vaccine development
Impurities generated during the In vitro transcription process
What kind of impact these impurities have on our immune system
How to generate a clean mRNA solution

Contributors

Sergio Linares-Fernández , Ph.D.

Dr. Sergio Linares-Fernández is a young researcher with a strong expertise in vaccines, immunology, and molecular biology. He graduated on Biotechnology at University of Cadiz (Spain) and continued the Master Erasmus Mundus Leading International Vaccinology Education in 5 different European universities and 3 countries (Spain, Belgium, and France). He pursued a PhD at the Tissue Biology and Therapeutic Engineering Laboratory in Lyon (France) titled "Optimizing an mRNA Vaccine platform against HIV-1: from the in vitro transcription design to envelope protein expression" where he optimized the RNA sequence backbone and combined different mRNA purification steps to decrease RNA immunogenicity/ PRR recognition to increase the mRNA translation efficiency in vitro. During his Ph.D. he also worked in the RNA formulation into LNPs and performed the in vivo proof of concept for 6 different HIV vaccine candidates. Recently, Sergio joined a new adventure in the R&D department of Sanofi Pasteur (France) as RNA Automation Expert at the mRNA Center of Excellence.

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Description

Contributors

Sergio Linares-Fernández , Ph.D.