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The oral absorption process consists of numerous hurdles that a drug needs to conquer before reaching systemic circulation. Drug release and absorption are quite complex considering the dynamic nature of the human gastrointestinal (GI) tract. Depending on (i) the desired systemic exposure and (ii) the associated pharmacodynamic effect, drug release can be triggered across the human GI tract as such to deliver the drug in a specific region at a specific release rate. In the particular interest of locally-acting drugs, numerous drug delivery strategies are developed to target drug release in assigned regions of the colon especially when interested in the treatment of inflammatory bowel diseases (e.g., ulcerative colitis). Reaching the most distal parts of the human GI tract is challenging as extra barriers need to be conquered compared to oral drug delivery in the more proximal parts. In the following series of webinars as organized by the Oral Biopharmaceutics and Modeling (OBAM) community of AAPS, an in-depth overview of (i) physiological aspects of the colonic environment, (ii) colonic-targeted formulations and (iii) predictions towards colonic absorption will be thoroughly discussed.
Part 3: Predicting Colonic Absorption
Prediction of colonic absorption is of high interest to guide development of extended-release formulations or just evaluating drug’s potential for colonic absorption to avoid the unnecessary experiments, in case when a drug absorbs poorly from the colon. Physiologically based absorption models are widely used for this purpose. Despite being imperfect, these models allow to save time and costs associated with in vivo studies. In this webinar, the most recent advancements in modeling of colonic absorption will be discussed.
- How the interplay between drug’s physico-chemical properties and colon physiology determine the extent of its colonic absorption
- Predictive power of mechanistic absorption modeling and its challenges
- Application of in vitro and in vivo animal studies to aid prediction of colonic absorption