Colonic Drug Absorption- Part 1: Colon Physiology and its Environment for Drug Absorption

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Description

The oral absorption process consists of numerous hurdles that a drug needs to conquer before reaching systemic circulation. Drug release and absorption are quite complex considering the dynamic nature of the human gastrointestinal (GI) tract. Depending on (i) the desired systemic exposure and (ii) the associated pharmacodynamic effect, drug release can be triggered across the human GI tract as such to deliver the drug in a specific region at a specific release rate. In the particular interest of locally-acting drugs, numerous drug delivery strategies are developed to target drug release in assigned regions of the colon especially when interested in the treatment of inflammatory bowel diseases (e.g., ulcerative colitis). Reaching the most distal parts of the human GI tract is challenging as extra barriers need to be conquered compared to oral drug delivery in the more proximal parts. In the following series of webinars as organized by the Oral Biopharmaceutics and Modeling (OBAM) community of AAPS, an in-depth overview of (i) physiological aspects of the colonic environment, (ii) colonic-targeted formulations and (iii) predictions towards colonic absorption will be thoroughly discussed.

Part 1: Colon Physiology and its Environment for Drug Absorption
Extent of colonic absorption of a drug is function of colon physiology and drug’s physico-chemical properties. For any given drug, its small intestinal absorption will be different than its colonic absorption due to the physiological and physiochemical differences between these two parts of the intestine. The first webinar of this series will focus on understanding colon physiology and its impact on drugs absorption.

Learning Objectives:

How changing physiology of the intestine (pH, fluid volume, amount of bile salts, surface area, transit time, porosity, expression levels of transporters) affects drug absorption.
How interplay between physico-chemical properties of the drug and colon physiology determines the extent of colonic absorption.
The difference between healthy and diseased colon and impact of disease on colonic absorption.

Contributors

Clive Wilson, Ph.D.

Clive Wilson is a Research Professor at Strathclyde University. He remains an active scientist, involved in global pharmaceutics projects in the USA and Europe across industry and academic groups. He was a past-president of the European Union Federation for Pharmaceutical Sciences (EUFEPS) and was the J. P. Todd Chair in Pharmaceutics at the University of Strathclyde until his formal retirement. Professor Wilson is still involved in teaching, examining and supervision of postgraduates and his research interests are divided between ophthalmology and gastroenterology, and he participates in networks across Europe regularly at conferences. He serves on several advisory boards in an educational role across the biological disciplines including AGePOP, which is an EU-funded training network looking at health needs of the elderly with regard to oral drug delivery and serves as an external assessor in the Marie Sklowdowska-Curie ocular drug delivery initiative Orbital. Professor Wilson has authored and edited six books, supervised 71 postgraduate student theses and has published more than four hundred articles in peer reviewed journals over a wide range of physiological pharmaceutics.

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Description

Contributors

Clive Wilson, Ph.D.