Update on Sotatercept from the Phase 2 Clinical Program: A Potential Therapy Targeting the Underlying Cause of PAH

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Description

Patients with PAH still face a devastating and progressive disease. This program will review the imbalances in BMPR-II and activin receptor signaling that may drive PAH progression, and will focus on an investigational therapeutic approach that aims to rebalance this signaling in the context of the latest data from ongoing clinical trials.

This program is sponsored by Acceleron.

By registering for this webinar, you agree your information will be shared with the sponsor.

No CME or MOC credits are available for this program.

Opinions expressed and resources shared may not have been reviewed by the ATS prior to distribution through ATS channels, or reflect official positions of the ATS, unless it is explicitly noted as a result of official ATS approval. References to specific commercial entities (companies) or products do not reflect review or endorsement by the ATS unless it is explicitly noted as a result of official ATS approval.

Contributors

Aaron B. Waxman, MD, PhD

Brigham and Women’s Hospital (BWH)
Director, Pulmonary Vascular Disease Program

Dr. Aaron B. Waxman is the director of the Pulmonary Vascular Disease Program at Brigham and Women’s Hospital (BWH). He is also an associate professor of medicine at Harvard Medical School.

After receiving his medical degree from Yale University School of Medicine, Dr. Waxman completed a residency in internal medicine at Yale New Haven Hospital. He then completed two fellowships: the first at Howard Hughes Medical Institute, and the second in pulmonary and critical care at Yale New Haven Hospital. He is board certified in critical care medicine, internal medicine and pulmonary disease.

Dr. Waxman’s clinical interests include pulmonary arterial hypertension (PAH), right heart failure, thromboembolic disease and pulmonary vascular disease. His research focuses on the inflammatory mechanisms of pulmonary vascular remodeling that lead to right heart failure. His research into the regulation of cell death proteins by IL-6 cytokines in mice led to the discovery of a relationship between dyspnea and mitochondrial dysfunction, and resulted in additional clinical studies examining the abnormalities of inflammatory mediators and oxygen extraction in patients with PAH. He has authored over 110 peer-reviewed publications and has received funding from the National Institutes of Health and the National Heart, Lung, and Blood Institute.

Thank you

Description

Contributors

Aaron B. Waxman, MD, PhD