Activity Overview

Although the recent availability of the novel enzyme replacement therapy (ERT) olipudase alfa has improved the outlook for patients with acid sphingomyelinase deficiency (ASMD), clinical outcomes remain poor as many patients go undiagnosed until presenting to hepatology or gastroenterology clinics with disease complications. This accredited continuing medical education symposium will use a case-based approach to provide hepatologists, gastroenterologists, and other healthcare providers with effective strategies to improve ASMD recognition, differential diagnosis, and management, including the use of novel ERT and supportive care measures as appropriate.

Target Audience
This initiative is intended for pediatric gastroenterologists, pediatric and adult hepatologists, transplant surgeons, pediatric and adult nutritionists/dieticians, intensivists/intensive care unit/critical care clinicians, nurses, and other HCPs who may be involved in the diagnosis and management of ASMD.

Agenda

• Overview
• A Case of Missed Opportunity for Diagnosis
• ASMD in the Gastroenterology and Hepatology Setting
• Preventing Progression in ASMD: The Era of Enzyme Replacement Therapy
• Suspecting and Confirming ASMD: Symptom Recognition and Differential Diagnosis
• Clinical Case Challenge: Addressing Missed Opportunities for Diagnosis
• Q&A and Closing Remarks

Learning Objectives
Upon successful completion of this activity, participants should be better able to:

• Recognize ASMD as a potential etiology for hepatosplenomegaly and other hepatic/gastroenterologic manifestations
• Identify multisystem clinical manifestations that are suggestive of ASMD
• Apply diagnostic algorithms and appropriate assays to rule out confounding diagnoses and make a differential diagnosis of ASMD
• Evaluate the efficacy and safety of ERT for pediatric and adult patients with ASMD
• Implement strategies to optimize multidisciplinary, individualized management of ASMD, considering the use of ERT and supportive care

This activity is jointly provided by AKH Inc., Advancing Knowledge in Healthcare and Catalyst Medical Education, LLC.

This activity is supported by an educational grant from Sanofi.

Disclosure
It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.

Criteria for Success
Certificates of completion will be awarded based on the participant’s attendance and submission of the activity evaluation/claim credit form. You must participate in the entire activity to receive credit. There is no fee to participate in this activity. If you have questions about this activity, please contact AKH Inc. at tbrignoni@akhcme.com.

Credit provided by AKH Inc., Advancing Knowledge in Healthcare

In support of improving patient care, this activity has been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and Catalyst Medical Education, LLC. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians
AKH Inc., Advancing Knowledge in Healthcare designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
1.5 ANCC contact hours.

Disclaimer
This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

Disclosure of Unlabeled Use and Investigational Product
This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

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