The shift to population health and new delivery models is generating a wave of partnerships among hospitals, physician networks, insurers and other health care providers. While these partnerships benefit patients and communities with increased access and quality of care, they may also pose potential challenges for Catholic health organizations when other-than-Catholic entities do not share all the moral teachings of the Catholic Church. Catholic organizations must carefully address these challenges in light of the Principle of Cooperation in order to morally navigate involvement with the wrongdoing of others.