In April 2020, the Rockefeller Foundation and Boston University School of Public Health launched the Commission on Health Determinants, Data, and Decision-Making, known as the 3-D Commission. The commission aimed to create a common language among social determinants of health, data science, and decision to improve public health and address health disparities that worsened under COVID-19 due to existing structural inequities. The commission report—the result of two years of research among experts in academia, the private sector, civil society, and government—explores the key social and economic drivers that influence health outcomes and illustrates how social determinants of health data can influence decisionmaking and public and private investments. This session will discuss the report, and its implications for better decisionmaking for global health.