The aim of this session proposal is to present the cutting-edge of science information on how each aspect of bonding to zirconia can influence longevity of zirconia restorations, clinical outcomes, and some new trends on the application of this material. Zirconia has been extensively used in manufacturing single crowns and/or 3-unit fixed partial dentures and recent clinical trials explored the fabrication of onlays/inlays and veneers, where bonding, rather than cementing, gain more importance. Nonetheless, bonding zirconia to resin cements is still a challenge due to the inert nature of the microstructure of this polycrystalline material. Zirconia microstructure is not susceptible to most acids with the exception of strong hazardous acids. The difficulties associated with roughening the zirconia surface to promote zirconia-resin cement micro-mechanical interlocking have been extensively explored in the literature. Moreover, inducing surface modifications can cause crystalline changes and accelerate hydrothermal and fatigue degradation. Therefore, novel and alternative techniques have been proposed. The use of ultrashort-pulse laser as one of those techniques was recently reported in the literature, and promising results were identified with increased roughness, wettability, and superior bond strength. In addition to the ultrashort laser techniques, chemical bonding has been exploited to enhance the quality of adhesive cementation and appropriate bond to zirconia. In short, the literature presented clarification on use of silanes and 10-methacryloxydecyl dihydrogen phosphate (MDP) as a determinant of the physico-chemical properties of the coating and the appropriateness of utilizing acid monomers MDP-content to bond.