2021 IADR/AADR/CADR General Session
The 99th General Session & Exhibition of the IADR was to be held in conjunction with the 50th Annual Meeting of the American Association for Dental Research and the 45th Annual Meeting of the Canadian Association for Dental Research, from July 21-24, 2021 as a Virtual Experience.The recordings in this library from the meeting are a selection of the science that was to be presented as part of the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers, the IADR Academy and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
The International Association for Dental Research is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Concerns or complaints about a CE provider may be directed to the provider or to the Commission for Continuing Education Provider Recognition at ADA.org/CERP.
Session Description
Dentistry has made enormous strides in the last century, particularly at better understanding the challenges and opportunities in endodontics pertaining to engineering a metabolically active and functional (blood carrying) dental pulp capable of forming new dentin. Of note, based on the rather unpredictable levels of success with current treatment modality (evoked bleeding), the last decade has witnessed major developments toward the generation of innovative multifunctional (e.g., antimicrobial, immunomodulating, regenerative) biomaterials therapeutics to devise cell-friendly disinfection and predictable pulp and dentin regeneration strategies. In this symposium, we anticipate to gather clinicians and researchers from around the globe, focusing on the emerging field of regenerative endodontics to promote discussion, interaction, and cross-discipline networking to underscore new discoveries and potential therapeutic platforms to advance clinical translation. In terms of novel biomaterials, latest developments in the synthesis of injectable and on-demand, that is matrix metalloproteinases-sensitive hydrogels for infection ablation and hard tissue regeneration will be discussed. Meanwhile, an innovative nitric oxide releasing biomimetic nanomatrix gel with proven disinfection and pulp-dentin tissue regeneration capacities will be highlighted. Furthermore, considering that wound repair involves a complex interplay between connective tissue matrix and host/immune cells under the influence of cytokines/mediators in a low bacterial load environment, this symposium will also discuss the ability of nanoparticles guided microtissue engineered dentin to inactive bacterial biofilm and modulate host/immune cells for tissue regeneration. Lastly, organoids, hDPSC derived extracellular vesicles, apical papilla constructs and biomaterials as tools for dental tissue regeneration, will also be addressed.
Learning Objectives
July 22, 2021
Presenters
Marco Bottino - Injectable MMP-Responsive Hydrogels for Infection Ablation and Hard Tissue Regeneration
Kyounga Cheon - Pulp-Dentin Regeneration Using Nitric Oxide Releasing Nanomatrix Gel
Anil Kishen - Immune Modulation by Nanoparticles Guided Matrix Stabilization: an Alternate Anti-Biofilm Strategy in Dentin-Pulp Engineering
Ivo Lambrichts - Organoids, Extracellular Vesicles and Apical Papilla as Tools for Dental Tissue Regeneration
Sponsoring Groups/Networks
Dental Materials, Microbiology/Immunology, Pharmacology/Therapeutics/Toxicology, Pulp Biology & Regeneration Research, Stem Cell Biology Research
CE Credits
1.5 Contact Hours
Financial Interest Disclosure:
NONE
Dentistry has made enormous strides in the last century, particularly at better understanding the challenges and opportunities in endodontics pertaining to engineering a metabolically active and functional (blood carrying) dental pulp capable of forming new dentin. Of note, based on the rather unpredictable levels of success with current treatment modality (evoked bleeding), the last decade has witnessed major developments toward the generation of innovative multifunctional (e.g., antimicrobial, immunomodulating, regenerative) biomaterials therapeutics to devise cell-friendly disinfection and predictable pulp and dentin regeneration strategies. In this symposium, we anticipate to gather clinicians and researchers from around the globe, focusing on the emerging field of regenerative endodontics to promote discussion, interaction, and cross-discipline networking to underscore new discoveries and potential therapeutic platforms to advance clinical translation. In terms of novel biomaterials, latest developments in the synthesis of injectable and on-demand, that is matrix metalloproteinases-sensitive hydrogels for infection ablation and hard tissue regeneration will be discussed. Meanwhile, an innovative nitric oxide releasing biomimetic nanomatrix gel with proven disinfection and pulp-dentin tissue regeneration capacities will be highlighted. Furthermore, considering that wound repair involves a complex interplay between connective tissue matrix and host/immune cells under the influence of cytokines/mediators in a low bacterial load environment, this symposium will also discuss the ability of nanoparticles guided microtissue engineered dentin to inactive bacterial biofilm and modulate host/immune cells for tissue regeneration. Lastly, organoids, hDPSC derived extracellular vesicles, apical papilla constructs and biomaterials as tools for dental tissue regeneration, will also be addressed.
Learning Objectives
- Provide the latest evidence on engineering MMP-responsive multifunctional biomaterials with disinfection and regenerative capabilities.
- Provide examples of how nitric oxide releasing nanomatrix gel can be used in regenerative endodontics.
- Present the clinical potential of nanoparticles-driven immunomodulation for root canal disinfection and pulp-dentin complex regeneration.
- Provide the potential of dental organoids, hDPSC derived EVs and apical papilla in regeneration of dental tissues.
July 22, 2021
Presenters
Marco Bottino - Injectable MMP-Responsive Hydrogels for Infection Ablation and Hard Tissue Regeneration
Kyounga Cheon - Pulp-Dentin Regeneration Using Nitric Oxide Releasing Nanomatrix Gel
Anil Kishen - Immune Modulation by Nanoparticles Guided Matrix Stabilization: an Alternate Anti-Biofilm Strategy in Dentin-Pulp Engineering
Ivo Lambrichts - Organoids, Extracellular Vesicles and Apical Papilla as Tools for Dental Tissue Regeneration
Sponsoring Groups/Networks
Dental Materials, Microbiology/Immunology, Pharmacology/Therapeutics/Toxicology, Pulp Biology & Regeneration Research, Stem Cell Biology Research
CE Credits
1.5 Contact Hours
NONE
