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Periodontal Disease and Neurodegenerative Diseases

2022 AADOCR/CADR Annunal Meeting

The 51st Annual Meeting of the AADOCR was held in conjunction with the 46th Annual Meeting of the Canadian Association for Dental Research, from March 14-26 as a hybrid experience with 839 individuals from 18 countries attending in person in Atlanta, GA and 692 individuals from 21 countries attending virtually. 

The recordings in this library from the meeting are a selection of the science that was to be presented as part of the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.

This session can be purchased as part of the full meeting recordings within the product bundles

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Session Description 
Evidence suggests that systemic inflammation is a possible stimulator of neuroinflammation. The precise etiology of the most common neurodegenerative disorders such as the sporadic Alzheimer’s disease (AD) remains to be discovered. Chronic neuroinflammation is a well-recognized component of neurodegenerative disorders but it is not fully established what triggers and perpetuates it in the brain. Periodontitis, a chronic, inflammatory disease of the gingivae induces systemic inflammation and can contribute to the development of neurodegenerative diseases. A greater cognitive decline was observed in AD patients suffering from chronic periodontitis. The field is moving fast from the association between periodontitis and clinical manifestations of neurodegeneration to studies on their causal mechanisms. This symposium will include newest findings from four scientists actively working on this topic. It will be a timely update on periodontal disease and neurodegenerative diseases that will be interested to both basic and clinical scientists of our scientific community.

Learning Objectives
  • Periodontal disease directly connected with neurodegenerative diseases through inflammation
  • New evidences support that periodontal pathogens cause neuroinflammation
  • Alteration of oral microbiome and metabolites in periodontitis contribute to systemic and neuroinflammation
Presentation Date
March 25, 2022

Xin Li
Ping Zhang
Alpdogan Kantarci - Inflammation as a Link between Periodontal Disease and Alzheimer Disease
Ping Zhang - Porphyromonas gingivalis promotes complement C1q-mediated microglia engulfment of synapses in Alzheimer’s mice
Hatice Hasturk - Porphyromonas gingivalis as a link between Periodontitis and Alzheimer’s disease
Xin Li - A common metabolite in host and microbiome connects periodontitis and neuroinflammation

Sponsoring Groups/Networks
Microbiology/Immunology Research, Periodontal Research

CE Credits
1.5 Contact Hours

Financial Interest Disclosure:

Not eligible for individual purchase must purchase as part of a meeting bundle.