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2022 Fall Focused Symposium: Session 2

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2022 Fall Focused Symposium: Accelerating Translation of Tissue Engineering and Regenerative Medicine Technologies in the Dental, Oral, and Craniofacial Space  
There have been significant strides in research in regenerative approaches to the repair and restoration of dental, oral, and craniofacial (DOC) tissues, ranging from bone graft materials to regenerative endodontics to temporomandibular joint repair. Yet few regenerative medicine therapies in the DOC space have been commercialized and widely adopted clinically. Difficulties in translation are related to scientific as well as non-scientific challenges. This symposium will highlight innovative tissue engineering/ regenerative medicine research in the DOC space, as well as layout the roadmap for overcoming challenges and translating technologies to the marketplace.

Learning Objectives
  • Attendees will increase their knowledge of cutting-edge regenerative medicine approaches to a variety of clinical challenges in the DOC space.
  • Attendees will increase their understanding of the technology commercialization pathway, from academic research to clinical trials to commercialization and beyond, including regulatory requirements and market development.
  • Attendees will be provided with an armamentarium of tools to approach translation of tissue engineering/ regenerative medicine research to the marketplace and beyond.

Time (EST) Presentation
2:00 p.m. Welcome Back
Jaques Nör, Donald A. Kerr Endowed Professor of Dentistry and Chair of the Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Immediate Past President, AADOCR
2:05 p.m. Core 4. Project Management/ Commercialization/ Financing (Core)
Jeffrey Scifert, Senior Engineering Program Manager, Medtronic.
2:25 p.m. Core 5. Designing Pre-/clinical Studies to Drive Clinical Adoption (Core)
Daniel Buser, Professor Emeritus, School of Dental Medicine, University of Bern.
2:45 p.m. ITP 3. Treating of Bone Peri-implantitis/ Implant Placement (ITP)
Tara Aghaloo, Professor of Oral and Maxillofacial Surgery, UCLA School of Dentistry
3:05 p.m. ITP 4. Treating of Bone Periodontitis (ITP)
Charles Sfeir, Director of the Center for Craniofacial Regeneration and Chair of the Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine
3:25 p.m. ITP 5. Regeneration of Soft Tissues (skin, muscles, salivary glands, mucosa, etc.)
Sarah Knox, Assistant Professor
Department of Cell & Tissue Biology, UCSF School of Dentistry

Chelsea Bahney, Principal Investigator and Program Director/Bone Repair and Skeletal Engineering, The Steadman Clinic & Steadman Philippon Research Institute) 
3:45 p.m. Closing Remarks
Jaques Nör, Donald A. Kerr Endowed Professor of Dentistry and Chair of the Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Immediate Past President, AADOCR

Contributors

  • Jacques Nör

    Email
    Jacques is the Donald Kerr Collegiate Professor of Dentistry and has served as Chair of the Department of Cariology, Restorative Sciences and Endodontics at the University of Michigan School of Dentistry since 2015. He has joint appointments as Professor of Otolaryngology (Medical School) and Professor of Biomedical Engineering (College of Engineering) at the University of Michigan. He is the current President of the American Association for Dental, Oral and Craniofacial Research (AADOCR). Jacques has served as Chair of the Oral Dental and Craniofacial Sciences (ODCS) NIH study section and is a member of the National Advisory Dental and Craniofacial Research Council (NADRC). He has published 215 peer-reviewed papers, 15 book chapters, and has been funded by the NIH since 2002. He has served as the Co-Director of the University of Michigan Head Neck SPORE. Jacques is a Fellow and past-Chair of the Section on Dentistry & Oral Health Sciences of the American Association for the Advancement of Sciences (AAAS), and recently became Fellow of the American Association for Dental Research (AADR). He received the Distinguished Scientist Award, the William J. Gies Award, and the Hatton Award from the International Association for Dental Research (IADR). Jacques is Associate Editor of the Journal of Dental Research and a member of several editorial boards. His research interests are in the study of the pathobiology of cancer stem cells in head neck squamous cell carcinoma and salivary gland cancer, as well the studies of mechanisms regulating dental pulp stem cell fate.

  • Daniel Buser

    Professor Emeritus, School of Dental Medicine, University of Bern
    Email

    Dr.DanielBuserhasbeenProfessorofOralSurgeryattheUniversityof Bern|Switzerland (2000-19). He also served as President of various academic associations including the EAO (1996/97), and the ITI (2009- 13).
    Daniel Buser has been active in translational research for more than 30 years, many of them pre-clinical studies. Main topics of interest have been implant surfaces, bone regeneration with barrier membranes(GBR technique), biological aspects of autografts and other bone fillers, and anatomic characteristics of the jaws using CBCT. With his team, he has authored and co-authored more than 400 publications and book chapters,many of them with high citation sindices.HeisalsoEditorand main author of the well-known GBR Book by Quintessence. His main activity is now Continuing Education. With his friend Toni Sculean, he has established the Buser & Sculean Academy for Periodontology and Implant Dentistry. The mission is knowledge sharing to the young generation of implant specialists around the globe using hybrid Master Courses.

  • Tara Aghaloo

    Professor of Oral and Maxillofacial Surgery, UCLA School of Dentistry
    Email

    Dr. Tara Aghaloo is Professor in Oral and Maxillofacial Surgery at the UCLA School of Dentistry. She completed her dental training at the University of Missouri-Kansas City, and Oral and Maxillofacial Surgery residency, M.D., and PhD in Oral Biology at UCLA. She is a diplomate of the American Board of Oral and Maxillofacial Surgery. Her research and clinical practice focuses on bone regeneration and remodeling, where a large part of her clinical practice is treating patients with peri-implantitis and failing implants. She has been a PI and co-Investigator on over 10 NIH research grants, and is the past chair of the DSR NIDCR study section.

  • Charles Sfeir

    Director of the Center for Craniofacial Regeneration and Chair of the Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine
    Email

    Dr. Sfeir is the Associate Dean for Research, Director of the Center for Craniofacial Regeneration and Chairman of the Department of Periodontics at the University of Pittsburgh. His research is multidisciplinary and translational in nature, focusing on developing therapies for craniofacial and dental diseases. Recently he has focused on 1) developing dental devices using resorbable metals for periodontal regeneration. 2) developing, in collaboration with Dr. Steve Little, chair of the department of Chemical Engineering at the University of Pittsburgh, novel treatment for periodontal disease by modulating the immune system which will be the focus of this presentation. Dr. Sfeir will present on behalf of Oraxsys Therapeutics. Launched by Orange Grove Bio in 2022, Oraxsys Therapeutics was founded with a mission to develop novel therapies for the treatment of periodontal and systemic immune pathologies. Autoimmune and inflammatory diseases commonly involve oral manifestations, and Oraxsys’ therapeutic microparticle technology allows for the controlled release of immune modulating agents directly to the oral mucosa, promoting restoration of proper immune cell function. Oraxsys is based on the work and discoveries of cofounders Dr. Charles Sfeir and Dr. Steven Little at the University of Pittsburgh and is being managed by Orange Grove Bio’s dedicated drug development team and Venture Partner Dr. Peter Alff.

  • Kim Martin

    Kimberly Martin, PhD is the founder and Principle at Boulder Clinical Science, a CRO specializing in helping start-ups design and execute clinical trials. Dr. Martin is a trained and well published clinical scientist, and brings 25 years of experience in translating drug, device, and biologics products from the bench to the clinic and the market. Dr. Martin spent over 20 years in industry at major firms such as Medtronic/Covidien and Zimmer Biomet in which she led clinical teams in design and execution of clinical trials, and in scientific and healthcare economic due diligence of acquisition target technologies. In her role at Boulder Clinical Science, Dr. Martin has extensive experience assisting small start-up companies with a clinical strategy that dovetails with business needs and regulatory strategy. Dr. Martin has served as a clinical liaison between the company and the FDA to bring hundreds of medical technologies to market. Dr. Martin earned her bachelor’s in molecular biology from the University of Missouri-Columbia and Her Masters and PhD in Clinical Science from the University of Colorado Anschutz Medical Campus. Dr. Martin is also a part time entrepreneur in residence for the National Heart, Lung, and Blood Institute.

  • Yang Chai

    University Professor, George and MaryLou Boone Chair in Craniofacial Molecular Biology; Director, Center for Craniofacial Molecular Biology; Associate Dean of Research, Ostrow School of Dentistry, University of Southern California
    Email

    Dr. Yang Chai is the University Professor and the George and MaryLou Boone Chair in Craniofacial Biology at the University of Southern California. He serves as the Director of the Center for Craniofacial Molecular Biology (CCMB) and Associate Dean of Research at the Herman Ostrow School of Dentistry of USC. Dr. Chai earned a DMD degree from Peking University School of Stomatology as well as DDS and PhD in Craniofacial Biology from the University of Southern California. He is most noted for his research on craniofacial development and birth defects, which has transformed the field and led to the successful rescue of cleft palate in mouse embryos. He also studies stem cells and is currently using innovative 3D-printed scaffolds seeded with stem cells to regenerate tissue for patients who have lost bone due to trauma, congenital defects, or disease.
    Dr. Chai is a member of the National Academy of Medicine. He is an elected member of the American Academy of Arts and Sciences (AAAS). Dr. Chai has authored more than 160 scientific papers and numerous book chapters, and recently edited a book on craniofacial development. Dr. Chai has been continuously funded by the National Institute of Health for more than 25 years. His work has earned him multiple awards including the NIH MERIT award and the 2011 IADR (International Association of Dental Research) Distinguished Scientist Award.

November 3, 2022
Thu 2:00 PM EDT

Duration 2H 0M

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