2022 IADR/APR General Session
The 100 th General Session & Exhibition of the IADR was held in conjunction with the 5th Meeting of the Asia Pacific Region. The virtual meeting was attended by individuals from around the world. Those attending the meeting could choose from among 207 Interactive Talk sessions, seven Focused Learning Sessions, three Hands-on Workshops, five satellite symposia, 52 Symposia, one Distinguished Lecture Series and a plenary.ÂThe recordings in this library from the meeting are a selection of the science that was to be presented as part of the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include the IADR Distinguished Lecture Series speaker and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
Description
When appropriately conducted and reported, randomized controlled trials (RCTs) play a significant role in the comparative effectiveness research world by providing evidence about the effects (i.e., desirable and undesirable effects) of various interventions. Its strength relies on the methodological strategies that investigators implement to minimize the influence of bias and confounding. Although RCTs are essential for clinical and policy decision-making, they need to be synthesized using unbiased summaries of the best available evidence: Systematic reviews. These types of reviews allow clinicians and policymakers to access the totality of the body of evidence addressing a particular healthcare matter and constitute the bricks to develop evidence-based clinical practice guidelines and policy. This virtuous series of research deliverables weaken every time that investigators conducting RCTs fail to appropriately address sources of bias and confounding before, during, and after a trial is completed, or when lack of adherence to reporting standards (e.g., CONSORT) or features of study design prevent systematic reviewers, guideline developers or policymakers from obtaining the necessary data to inform their decisions. The former issue includes, for example, a suboptimal selection of outcomes (e.g., surrogates over patient-important outcomes), a narrow selection of patients based on their prognostic factors and demographics, insufficient description of the intervention under testing that makes its implementation unfeasible, or incomplete or selective reporting of treatment effects. Thus, the purpose of this symposium is to provide essential study design and reporting insights to investigators conducting RCTs to maximize relevance for decision-making and appropriateness for inclusion in systematic reviews and meta-analyses.
Learning Objectives
Presentation Date
June 23, 2022
Presenters
Margherita Fontana - Methods to Minimize Risk of Bias of RCTs in Cariology
Jan Clarkson - Methods to Increase Applicability of RCTs in Cariology
Alonso Carrasco-Labra - Optimal Reporting of RCTs in Cariology and Inclusion in Systematic Reviews, Policy, and Clinical Practice Guidelines
Sponsoring Groups/Networks
Cariology Research, Clinical and Translational Science Network, Evidence-based Dentistry Network
CE Credits
Not Eligible
Financial Interest Disclosure:
None
When appropriately conducted and reported, randomized controlled trials (RCTs) play a significant role in the comparative effectiveness research world by providing evidence about the effects (i.e., desirable and undesirable effects) of various interventions. Its strength relies on the methodological strategies that investigators implement to minimize the influence of bias and confounding. Although RCTs are essential for clinical and policy decision-making, they need to be synthesized using unbiased summaries of the best available evidence: Systematic reviews. These types of reviews allow clinicians and policymakers to access the totality of the body of evidence addressing a particular healthcare matter and constitute the bricks to develop evidence-based clinical practice guidelines and policy. This virtuous series of research deliverables weaken every time that investigators conducting RCTs fail to appropriately address sources of bias and confounding before, during, and after a trial is completed, or when lack of adherence to reporting standards (e.g., CONSORT) or features of study design prevent systematic reviewers, guideline developers or policymakers from obtaining the necessary data to inform their decisions. The former issue includes, for example, a suboptimal selection of outcomes (e.g., surrogates over patient-important outcomes), a narrow selection of patients based on their prognostic factors and demographics, insufficient description of the intervention under testing that makes its implementation unfeasible, or incomplete or selective reporting of treatment effects. Thus, the purpose of this symposium is to provide essential study design and reporting insights to investigators conducting RCTs to maximize relevance for decision-making and appropriateness for inclusion in systematic reviews and meta-analyses.
Learning Objectives
- Understand the most important methodological strategies to minimize risk of bias in randomized controlled trials in cariology (Randomization, allocation concealment, blinding, missing participant data issues, intention to treat, trial protocol and registration, etc.)
- Understand key methodological strategies to increase the applicability of randomized controlled trials in cariology to policy and practice (Pragmatic vs explanatory trials, narrow vs wide eligibility criteria, patients/population characteristics, description of the interventions, outcome selection, patient-reported outcomes, etc.)
- Familiarize with the most important reporting aspects of randomized controlled trials in cariology and its inclusion in systematic reviews, policy, and clinical practice guidelines (statistical analysis, participant’s demographics, effect modifiers, outcome reporting [patient-important and patient-reported outcome measures], presentation of treatment effect estimates, subgroup analysis, use of minimal important difference, etc.)
Presentation Date
June 23, 2022
Presenters
Margherita Fontana - Methods to Minimize Risk of Bias of RCTs in Cariology
Jan Clarkson - Methods to Increase Applicability of RCTs in Cariology
Alonso Carrasco-Labra - Optimal Reporting of RCTs in Cariology and Inclusion in Systematic Reviews, Policy, and Clinical Practice Guidelines
Sponsoring Groups/Networks
Cariology Research, Clinical and Translational Science Network, Evidence-based Dentistry Network
CE Credits
Not Eligible
None
Not eligible for individual purchase must purchase as part of a meeting bundle.