2023 AADOCR/CADR Annual Meeting
The 2023 AADOCR/CADR Annual Meeting & Exhibition provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Portland, Oregon. The meeting was attended by 2,054 individuals from 39 countries.The recordings in this library from the meeting are a selection of the science that was presented at the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
Pain is well understood to be an important driver of dental care utilization and often the most feared and important outcome of dental procedures to patients. Intriguingly, there is mounting evidence that nociceptors, the neurons that transmit pain signaling to the central nervous system upon detection of potential tissue damage, also critically modulate the progression of pathogen mediated diseases. Sensory neurons can directly detect multiple bacterial products, including LPS, flagellin, and N-formylated peptides. These bacterial products activate and sensitize sensory neurons, causing pain and the release of neuropeptides, which in turn have a profound effect on the immune response by enhancing or inhibiting immune cell recruitment and activation. Ultimately the pathogen mediated neuronal activity can either enhance or inhibit the disease progression depending upon the unique environment of the affected tissue. As multiple dental diseases are pathogen mediated, understanding pathogen elicited sensory neuron signaling is critical to better understand the pathophysiology of such conditions. In this symposium we will present research relating to the mechanisms by which bacteria activate and sensitize trigeminal neurons through patter recognition receptor and transient receptor potential signaling pathways. We will also present recent research demonstrating how nociceptor modulation of pathogen mediated inflammatory processes can occur in the dental pulp and periodontal tissues. We will also discuss opportunities for future novel therapeutic approaches that harness neuronal pathways to modulate pathogen mediated oral diseases.
Learning Objectives
Thursday, March 16, 2023
Presenters
Neuroscience
CE Credits
1.5 Hours
Financial Interest Disclosure:
None
Pain is well understood to be an important driver of dental care utilization and often the most feared and important outcome of dental procedures to patients. Intriguingly, there is mounting evidence that nociceptors, the neurons that transmit pain signaling to the central nervous system upon detection of potential tissue damage, also critically modulate the progression of pathogen mediated diseases. Sensory neurons can directly detect multiple bacterial products, including LPS, flagellin, and N-formylated peptides. These bacterial products activate and sensitize sensory neurons, causing pain and the release of neuropeptides, which in turn have a profound effect on the immune response by enhancing or inhibiting immune cell recruitment and activation. Ultimately the pathogen mediated neuronal activity can either enhance or inhibit the disease progression depending upon the unique environment of the affected tissue. As multiple dental diseases are pathogen mediated, understanding pathogen elicited sensory neuron signaling is critical to better understand the pathophysiology of such conditions. In this symposium we will present research relating to the mechanisms by which bacteria activate and sensitize trigeminal neurons through patter recognition receptor and transient receptor potential signaling pathways. We will also present recent research demonstrating how nociceptor modulation of pathogen mediated inflammatory processes can occur in the dental pulp and periodontal tissues. We will also discuss opportunities for future novel therapeutic approaches that harness neuronal pathways to modulate pathogen mediated oral diseases.
Learning Objectives
- Understand the mechanisms by which the bacterial toxin LPS can activate and sensitize trigeminal sensory neurons.
- Understand how the neuropeptide calcitonin gene related peptide (CGRP) impacts pain behaviors and immune cell recruitment using a mouse model of pulpitis.
- Understand the contribution of nociceptive nerves on host responses and the progression of periodontitis.
Thursday, March 16, 2023
Presenters
- Jennifer Gibbs - Sensory neuron-immune interactions and relevance to dental diseases.
- Ozge Erdogan - The neuropeptide CGRP modulates inflammation during pulpitis.
- Man-Kyo Chung - Nociceptor modulation of periodontitis
- Christopher Donnelly - STING signaling in peripheral sensory neurons in inflammation and host defense
Neuroscience
CE Credits
1.5 Hours
None
