2023 AADOCR/CADR Annual Meeting
The 2023 AADOCR/CADR Annual Meeting & Exhibition provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Portland, Oregon. The meeting was attended by 2,054 individuals from 39 countries.The recordings in this library from the meeting are a selection of the science that was presented at the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
The International Association for Dental Research is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Concerns or complaints about a CE provider may be directed to the provider or to the Commission for Continuing Education Provider Recognition at ADA.org/CERP.
Session Description
Many autoimmune conditions are triggered by viral infection. Viral-mediated mechanisms of autoimmune Sjögren's pathogenesis and salivary gland dysfunction are not fully understood. However, significant recent evidence has revealed several mechanisms by which viral infection promotes salivary gland dysfunction. For instance, LAMP3, a lysosome-associated membrane protein induced following Influenza A infection, is elevated in the minor salivary glands of Sjögren's patients and is important for autoantigen release. Epstein-Barr virus (EBV) infection causes glandular epithelitis and may contribute to autoimmune Sjögren's by mediating B and T-cell differentiation that contribute to Sjögren's pathogenesis. Hepatitis Delta Virus infection in mice produces a Sjögren's-like disease phenotype. Each of these points to the importance of viral infection in Sjögren's pathogenesis. This session features four speakers, each who discusses viral-mediated salivary gland dysfunction in the context of a different virus. Attendees will better understand the commonalities and differences among infections of the salivary glands and how they may mediate dysfunction. This timely session will discuss important concepts of viral-mediated autoimmunity and salivary gland dysfunction as the broader scientific community continues to explore the long-term effects of SARS-CoV2 infection, including the effect(s) on salivary gland function and the oral cavity.
Learning Objectives
Wednesday, March 15, 2023
Presenters
Salivary Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
NONE
Many autoimmune conditions are triggered by viral infection. Viral-mediated mechanisms of autoimmune Sjögren's pathogenesis and salivary gland dysfunction are not fully understood. However, significant recent evidence has revealed several mechanisms by which viral infection promotes salivary gland dysfunction. For instance, LAMP3, a lysosome-associated membrane protein induced following Influenza A infection, is elevated in the minor salivary glands of Sjögren's patients and is important for autoantigen release. Epstein-Barr virus (EBV) infection causes glandular epithelitis and may contribute to autoimmune Sjögren's by mediating B and T-cell differentiation that contribute to Sjögren's pathogenesis. Hepatitis Delta Virus infection in mice produces a Sjögren's-like disease phenotype. Each of these points to the importance of viral infection in Sjögren's pathogenesis. This session features four speakers, each who discusses viral-mediated salivary gland dysfunction in the context of a different virus. Attendees will better understand the commonalities and differences among infections of the salivary glands and how they may mediate dysfunction. This timely session will discuss important concepts of viral-mediated autoimmunity and salivary gland dysfunction as the broader scientific community continues to explore the long-term effects of SARS-CoV2 infection, including the effect(s) on salivary gland function and the oral cavity.
Learning Objectives
- Learn how viral pathogens mediate salivary gland dysfunction and Sjögren's pathogenesis.
- Explore the differences among viral-mediated mechanisms that result from different infections, including Hepatitis Delta Virus, Influenza A, and Epstein-Barr Virus (EBV).
- Identify commonalities among viral-mediated mechanisms that may extend to additional viruses, including SARS-CoV2 infection.
Wednesday, March 15, 2023
Presenters
- John Chiorini - What is the Connection Between Sjögren's and Infection?
- Harini Bagavant - Innate Immunity Activation in Sjögren's Syndrome: Viral Triggers or Endogenous Ligands?
- Robert Hal Scofield - Epstein Barr Virus and Sjögren's
- Melodie Weller - Mechanisms of Hepatitis Delta Virus-mediated Salivary Gland Dysfunction
Salivary Research
CE Credits
1.5 Hours
NONE
