2023 AADOCR/CADR Annual Meeting
The 2023 AADOCR/CADR Annual Meeting & Exhibition provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Portland, Oregon. The meeting was attended by 2,054 individuals from 39 countries.The recordings in this library from the meeting are a selection of the science that was presented at the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
Autoimmune conditions predominantly affect women. Among these, Sjögren's is extremely sexually dimorphic; more than 90% of patients are female. The mechanism for this strong sex bias remained largely unknown for many years. In 2016, an X chromosome dose effect was reported where trisomy X (47,XXX) increased female risk of developing Sjögren's , and men with Klinefelterâ's syndrome (47,XXY) were at a similar risk of developing Sjögren's than women with two X chromosomes (46,XX). Abnormal X chromosome inactivation is also involved in Sjögren's pathogenesis. Sjögren's patients have elevated expression levels of the long non-coding RNA, X-inactive specific transcript (XIST), and its positive transcriptional regulators and methylation defects resulting in aberrant X chromosome inactivation have also been implicated. Speakers in this session will unveil their recent findings in identifying the sex-linked genes and subsequent biological processes that mediate this dose effect and the epigenetic processes that affect X chromosome inactivation, influencing Sjögren's pathogenesis. Further, the implications of this sexual dimorphism in pathogenic triggers of Sjögren's such as SARS-CoV2 infection will be explored. Understanding Sjögren's etiology with respect to sex dependence is integral to developing therapeutics for a disease largely devoid of curative options.
Learning Objectives
Friday, March 17, 2023
Presenters
Salivary Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
None
Autoimmune conditions predominantly affect women. Among these, Sjögren's is extremely sexually dimorphic; more than 90% of patients are female. The mechanism for this strong sex bias remained largely unknown for many years. In 2016, an X chromosome dose effect was reported where trisomy X (47,XXX) increased female risk of developing Sjögren's , and men with Klinefelterâ's syndrome (47,XXY) were at a similar risk of developing Sjögren's than women with two X chromosomes (46,XX). Abnormal X chromosome inactivation is also involved in Sjögren's pathogenesis. Sjögren's patients have elevated expression levels of the long non-coding RNA, X-inactive specific transcript (XIST), and its positive transcriptional regulators and methylation defects resulting in aberrant X chromosome inactivation have also been implicated. Speakers in this session will unveil their recent findings in identifying the sex-linked genes and subsequent biological processes that mediate this dose effect and the epigenetic processes that affect X chromosome inactivation, influencing Sjögren's pathogenesis. Further, the implications of this sexual dimorphism in pathogenic triggers of Sjögren's such as SARS-CoV2 infection will be explored. Understanding Sjögren's etiology with respect to sex dependence is integral to developing therapeutics for a disease largely devoid of curative options.
Learning Objectives
- Learn about the known mechanisms underlying sex bias in Sjögren's
- Learn about the effect of sexual dimorphism on risk factors of autoimmune triggers such as pathogenic infection
- Integrate recent findings to create a more holistic view of the sex-dependent factors mediating Sjögren's pathogenesis
Friday, March 17, 2023
Presenters
- Valerie Lewis - X Chromosome and the Sex Bias of Sjögren's Disease
- Yun Liang - Skewing in X-linked gene expression as a molecular explanation for sexual dimorphism in Sjögren's syndrome
- Brij Singh - Do epigenetic changes lead to Sjögren's Syndrome?
- Cuong Nguyen - Evidence of SARS-CoV-2 induces Sjögren's syndrome differently in males and females
Salivary Research
CE Credits
1.5 Hours
None
