2023 AADOCR/CADR Annual Meeting
The 2023 AADOCR/CADR Annual Meeting & Exhibition provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Portland, Oregon. The meeting was attended by 2,054 individuals from 39 countries.The recordings in this library from the meeting are a selection of the science that was presented at the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
3D micro physiological systems are in vitro platforms, which are being utilized as preclinical models and would organs-on-a-chips, which are 3D in vitro preclinical micro physiological systems fabricated with microchip manufacturing methods that contain continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. These devices model the key functions of organ replicating multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and liquid perfusion producing levels of tissue and organ functionality not possible with conventional 2D or 3D culture systems. Microfluidic devices also enable high-resolution, real-time imaging and in-vitro analysis of biochemical, genetic, and metabolic activities of living cells in a functional tissue and organ context, making them a very useful platform to test drugs and other materials.
These features of microfluidic organ-on-chip systems have enabled the reconstruction of native physiology of human tissues and the complex interactions between cells, matrix, microbiome and/or external environment. This has led to exponential increase in the application of organ-on-chip systems across various organ systems in the body. In the last 5 years, these next-generation tools have gained traction in dental and craniofacial research. Some examples include skin-on-chip, tooth-on-chip, oral mucosa-on-chip, salivary tissue-on-chip and bone-on-chip. Eventually, these micro-physiological systems aim to
This symposium aims to present the applications of these next-generation microfluidic and organ-on-chip technologies in dental, oral and craniofacial research.
Learning Objectives
Saturday, March 18, 2023
Presenters
Craniofacial Biology Research, Stem Cell Biology Research, Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
None
3D micro physiological systems are in vitro platforms, which are being utilized as preclinical models and would organs-on-a-chips, which are 3D in vitro preclinical micro physiological systems fabricated with microchip manufacturing methods that contain continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. These devices model the key functions of organ replicating multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and liquid perfusion producing levels of tissue and organ functionality not possible with conventional 2D or 3D culture systems. Microfluidic devices also enable high-resolution, real-time imaging and in-vitro analysis of biochemical, genetic, and metabolic activities of living cells in a functional tissue and organ context, making them a very useful platform to test drugs and other materials.
These features of microfluidic organ-on-chip systems have enabled the reconstruction of native physiology of human tissues and the complex interactions between cells, matrix, microbiome and/or external environment. This has led to exponential increase in the application of organ-on-chip systems across various organ systems in the body. In the last 5 years, these next-generation tools have gained traction in dental and craniofacial research. Some examples include skin-on-chip, tooth-on-chip, oral mucosa-on-chip, salivary tissue-on-chip and bone-on-chip. Eventually, these micro-physiological systems aim to
This symposium aims to present the applications of these next-generation microfluidic and organ-on-chip technologies in dental, oral and craniofacial research.
Learning Objectives
- Educate the wider dental community on ‘what are organ-on-chip systems, and their potential opportunities in dental and craniofacial research
and discuss the recent applications of the microfluidic and organ-on-chip technologies in dental and craniofacial research, - Demonstrate applications of microphysiological systems in assessment of safety, toxicity, biocompatibility, and drug absorption of dental/oral-care products.
- Demonstrate pathophysiological mechanisms involved in oral mucosa, skin, salivary glands and bone tissues.
Saturday, March 18, 2023
Presenters
- Gopu Sriram - Microfluidic Strategies to Emulate Host-Material and Host-Microbiome Interactions in Dental and Periodontal Disease
- Stella Alimperti - New perspectives of 3D Microphysiological systems for craniofacial tissue regeneration.
- Daniel Harrington - Keeping your ducts in a row: New concepts in salivary biomanufacturing
- Cristiane Franca - Collagen microarchitecture and stiffness affect vascular homeostasis
Craniofacial Biology Research, Stem Cell Biology Research, Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
None
