2023 AADOCR/CADR Annual Meeting
The 2023 AADOCR/CADR Annual Meeting & Exhibition provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Portland, Oregon. The meeting was attended by 2,054 individuals from 39 countries.The recordings in this library from the meeting are a selection of the science that was presented at the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
This symposium will highlight new emerging themes and ideas associated with microRNAs in craniofacial development, tissue repair, and regeneration.
Dr. Chen: miRNAs are emerging as new and powerful drug targets and have been used in regenerative medicine. Our studies have demonstrated that miR-335-5p has important dual-effects: inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation. Therefore, miR-335-5p is a potent pharmaceutic agent for treating osteoporosis and its related bone disorders. We will highlight our cutting-edge targeted nanoparticle system as a delivery vehicle.
Dr. Ravindran: Recent studies have highlighted that the miRNA cargo of extracellular vesicles (EVs) are one of the primary drivers of EV function. Our lab has investigated changes to mesenchymal stem cell (MSC) EV miRNA cargo upon changes to MSC cell state. The differentiation or pre-conditioning of MSCs significantly influences its EV miRNA composition to elicit pathway specific functions. The talk will feature the role of MSC EV miRNA immunomodulation and bone healing and elucidate new miRNA based EV engineering approaches.
Dr. Iwata: Various environmental factors, such as smoking, maternal alcohol consumption and abnormal diets, have been implicated as a risk of craniofacial malformations. Expression of miRNAs, is influenced by environmental factors and negatively regulates target gene expression at the post-transcriptional level. I will discuss the contribution of miRNAs in craniofacial birth defects induced by environmental risk factors and whether normalization of pathogenic miRNAs can be a potential preventive intervention.
Dr. Maruyama: Will present research on the role of microRNAs in bone development. Research has identified endogenous skeletal stem cells, which can contribute directly to bone repair by replacing damaged tissue.
Learning Objectives
Friday, March 17, 2023
Presenters
Stem Cell Biology Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
NONE
This symposium will highlight new emerging themes and ideas associated with microRNAs in craniofacial development, tissue repair, and regeneration.
Dr. Chen: miRNAs are emerging as new and powerful drug targets and have been used in regenerative medicine. Our studies have demonstrated that miR-335-5p has important dual-effects: inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation. Therefore, miR-335-5p is a potent pharmaceutic agent for treating osteoporosis and its related bone disorders. We will highlight our cutting-edge targeted nanoparticle system as a delivery vehicle.
Dr. Ravindran: Recent studies have highlighted that the miRNA cargo of extracellular vesicles (EVs) are one of the primary drivers of EV function. Our lab has investigated changes to mesenchymal stem cell (MSC) EV miRNA cargo upon changes to MSC cell state. The differentiation or pre-conditioning of MSCs significantly influences its EV miRNA composition to elicit pathway specific functions. The talk will feature the role of MSC EV miRNA immunomodulation and bone healing and elucidate new miRNA based EV engineering approaches.
Dr. Iwata: Various environmental factors, such as smoking, maternal alcohol consumption and abnormal diets, have been implicated as a risk of craniofacial malformations. Expression of miRNAs, is influenced by environmental factors and negatively regulates target gene expression at the post-transcriptional level. I will discuss the contribution of miRNAs in craniofacial birth defects induced by environmental risk factors and whether normalization of pathogenic miRNAs can be a potential preventive intervention.
Dr. Maruyama: Will present research on the role of microRNAs in bone development. Research has identified endogenous skeletal stem cells, which can contribute directly to bone repair by replacing damaged tissue.
Learning Objectives
- To understand the powerful role that microRNAs have as therapeutic reagents
- Extracellular vesicles (EVs) are derived from specific cell types and can transmit microRNAs from cell to cell or in tissues to regulate cellular processes.
- Environmental factors can play a major role in craniofacial and dental diseases and microRNA expression can be influenced by specific environmental risk factros.
Friday, March 17, 2023
Presenters
- Jake Jinkun Chen - miR-335-5p is a potent pharmaceutic agent for treating osteoporosis and its related bone disorders
- Sriram Ravindran - MSC EV miRNA immunomodulation and bone healing
- Junichi Iwata - Environmental factors and microRNAs associated with cleft lip and palate
- Takamitsu Maruyama - MicroRNA-mediated regulation of craniofacial and body bones
Stem Cell Biology Research
CE Credits
1.5 Hours
NONE
