2023 AADOCR/CADR Annual Meeting
The 2023 AADOCR/CADR Annual Meeting & Exhibition provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Portland, Oregon. The meeting was attended by 2,054 individuals from 39 countries.The recordings in this library from the meeting are a selection of the science that was presented at the Annual Meeting. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
Mucin proteins in saliva are responsible for the unique physicochemical properties of saliva that include lubrication, viscosity, and barrier function. A dense array of O-glycans attached to the mucin protein backbone provide mucins with their typical functions. Recently, with the help of novel glycomics approaches, we have gained better insights into the significance of these O-glycans. The O-glycans also form an interface for interactions with the oral microbiota allowing commensal bacteria to attach to saliva-coated surfaces in the mouth. Conversely, mucins can also aggregate microbes and thus aid in the clearance of unwanted pathogens. Such host-microbe interactions likely acted as selective drivers of mucin and glycan evolution during host-microbe coevolution. A better understanding of the structural and functional properties of mucins will help in the generation of artificial mucin analogues that can be used in the composition of novel artificial saliva surrogates.
Learning Objectives
Saturday, March 18, 2023
Presenters
Salivary Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
NONE
Mucin proteins in saliva are responsible for the unique physicochemical properties of saliva that include lubrication, viscosity, and barrier function. A dense array of O-glycans attached to the mucin protein backbone provide mucins with their typical functions. Recently, with the help of novel glycomics approaches, we have gained better insights into the significance of these O-glycans. The O-glycans also form an interface for interactions with the oral microbiota allowing commensal bacteria to attach to saliva-coated surfaces in the mouth. Conversely, mucins can also aggregate microbes and thus aid in the clearance of unwanted pathogens. Such host-microbe interactions likely acted as selective drivers of mucin and glycan evolution during host-microbe coevolution. A better understanding of the structural and functional properties of mucins will help in the generation of artificial mucin analogues that can be used in the composition of novel artificial saliva surrogates.
Learning Objectives
- Learn about the significance of O-glycans on salivary mucins, including their interactions with oral commensal microbes, and their study using novel glycomics approaches.
- Learn about the evolutionary mechanisms and selective pressures that have led to the generation of mucin proteins.
- Learn about novel approaches to generate and test synthetic mucin surrogates.
Saturday, March 18, 2023
Presenters
- Lawrence A. Tabak - Exploring the O-Glycome
- Omer Gokcumen - A mechanism of gene evolution generating mucin function
- Barbara Bensing - Interaction of commensal streptococci with salivary mucins
- Kamil Godula - Artificial mucin analogues
Salivary Research
CE Credits
1.5 Hours
NONE
