2023 IADR/LAR General Session with WCPD
The 2023 IADR/LAR General Session & Exhibition with WCPD provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Bogotá, Colombia. The meeting was attended by 1,667 individuals from 76 countries.The recordings in this library from the meeting are a selection of the science that was presented at the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
In recent years, endodontics has experienced significant progress in regenerative approaches, thanks to Regenerative Endodontic Therapy (RET). Initially, RET was based on a blood clot induced by apical hemorrhage without removing the patient's cells or cell-free RET. Later, RET encompassed the three principles of tissue engineering: stem cells, scaffolds, and growth factors, with the goal of regenerating a functional pulp. One of the main challenges of RET is to achieve disinfection of the root canal system; the literature has shown that this aspect is very necessary for success. To promote the expected pulp regeneration, it is necessary to know the role of bacterial virulence factors and develop optimal antimicrobial approaches for adequate disinfection of infected roots while ensuring the survival, recruitment, proliferation, and differentiation of stem cells in RETs. Recent improvements in scaffold-free therapy include the use of nanoparticles based on nanostructured polymeric gels of smaller size, which would allow obtaining an effective antibacterial activity, generating a possible alternative intracanal dressing for persistent endodontic diseases. On the other hand, the use of extracellular vesicles (EVs) released from stem cells shows potent proangiogenic and immunomodulatory effects, which have been investigated in a variety of diseases and inflammations and show promise in RET. This symposium provides useful in vitro and clinical evidence for practitioners to understand the challenges they face in achieving successful RET and the importance of preserving or restoring tooth vitality. The clinical translation of these current bioengineering approaches will undoubtedly be beneficial to the future practice of endodontics
Learning Objectives
Friday, June 23, 2023
Session Organizer/Chair
claudia brizuela (Corresponding Organizer)
Gabriela Sanchez (Organizer)
Tatiana Botero (Chair)
Hal Duncan (Chair)
Presenters
Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
NONE
In recent years, endodontics has experienced significant progress in regenerative approaches, thanks to Regenerative Endodontic Therapy (RET). Initially, RET was based on a blood clot induced by apical hemorrhage without removing the patient's cells or cell-free RET. Later, RET encompassed the three principles of tissue engineering: stem cells, scaffolds, and growth factors, with the goal of regenerating a functional pulp. One of the main challenges of RET is to achieve disinfection of the root canal system; the literature has shown that this aspect is very necessary for success. To promote the expected pulp regeneration, it is necessary to know the role of bacterial virulence factors and develop optimal antimicrobial approaches for adequate disinfection of infected roots while ensuring the survival, recruitment, proliferation, and differentiation of stem cells in RETs. Recent improvements in scaffold-free therapy include the use of nanoparticles based on nanostructured polymeric gels of smaller size, which would allow obtaining an effective antibacterial activity, generating a possible alternative intracanal dressing for persistent endodontic diseases. On the other hand, the use of extracellular vesicles (EVs) released from stem cells shows potent proangiogenic and immunomodulatory effects, which have been investigated in a variety of diseases and inflammations and show promise in RET. This symposium provides useful in vitro and clinical evidence for practitioners to understand the challenges they face in achieving successful RET and the importance of preserving or restoring tooth vitality. The clinical translation of these current bioengineering approaches will undoubtedly be beneficial to the future practice of endodontics
Learning Objectives
- Determine the future challenges of RETs to achieve translation to the clinic an discuss the different approaches to cell-based and cell-free endodontic regenerative therapies.
- Understand current and future concerns and developments of the role of bacterial virulence factors in RET.
- Evaluate the antibacterial activity and biocompatibility of silver and copper nanoparticles based on nanostructured polymeric gels.
Friday, June 23, 2023
Session Organizer/Chair
claudia brizuela (Corresponding Organizer)
Gabriela Sanchez (Organizer)
Tatiana Botero (Chair)
Hal Duncan (Chair)
Presenters
- claudia brizuela - Basic research and translational opportunities for regenerative endodontic therapy
- Gabriela Sanchez - New approaches for disinfection in RET based on nanotechnology
- Mauricio Garrido - Cellular proliferation and senescence of apical papilla cells to bacterial virulence factors
Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
NONE
