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Alexis Kalergis - "Immunology and Immunotherapy: Impairment of Immunological and Neurological Synapses as Virulence Mechanisms of Respiratory Viruses"

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2023 IADR/LAR General Session with WCPD

The 2023 IADR/LAR General Session & Exhibition with WCPD provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Bogotá, Colombia. The meeting was attended by 1,667 individuals from 76 countries.     

The recordings in this library from the meeting are a selection of the science that was presented at the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.

This session can be purchased as part of the full meeting recordings within the product bundles

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Alexis Kalergis

Pontificia Universidad Católica de Chile

Distinguished Lecture Series
Respiratory viruses are a leading public health burden worldwide due to inefficient viral immunity in the host. By inducing an excessive inflammatory response, these viruses can cause severe symptoms in the respiratory and nervous tissues, such as bronchiolitis and encephalopathy. In addition, some respiratory viruses impair T cell and dendritic cell function by suppressing the immunological synapse assembly. This could be a significant virulence factor to evade host immunity and enhance susceptibility to reinfection. Respiratory viruses can also cause learning impairment due to alterations in the blood-brain barrier and inflammation in the central nervous system after infection and the entry of immune system components to the CNS, damaging the function of neurons and astrocytes. These data have contributed to novel vaccine approaches to strengthen the immunological synapse leading to a safe and efficacious immunity capable of protecting against respiratory pathogens, such as RSV and SARS-CoV-2. The immunity triggered by these vaccines can also reduce CNS damage caused by respiratory viruses.

Learning Objectives
  • Attendees will learn about
    immunology and immunotherapy.
Presentation Date
Wednesday, June 24, 2023

CE Credits
1.5 Hours

Financial Interest Disclosure:

Not eligible for individual purchase must purchase as part of a meeting bundle.