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The IASP Pain Research Forum will host a seminar with Felipe A. Court, PhD, Universidad Mayor, Chile.
Here is an abstract of Dr. Court's talk:
Axonal degeneration is an active process involved in a variety of neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This non-apoptotic degenerative mechanism can cause permanent loss of function, so it represents a focus for neuroprotective strategies. Axonal degeneration is characterized by NAD+ depletion by SARM1 activation, increase in axonal ROS and Ca2+, and opening of the mitochondrial permeability transition pore. In addition, we have recently discovered that necroptosis activation is associated with axonal degeneration after a variety of stimuli. Importantly, defining the cascade for axonal degeneration might lead to the identification of potential targets for therapeutic intervention in a variety of conditions that lead to axonal loss.