Skip to main content

IASP PRF Seminar: Axonal Degeneration as a Target for Therapeutic Strategies in Central Neurodegeneration and Peripheral Neuropathies

Thank you

This live web event has ended. Thank you for attending.


If you have registered for this webinar, please ensure you are logged in before proceeding to the live webinar. The log in appears in the top right corner. You will see your name displayed if you are already logged in.

  • PRF webinars are a complimentary IASP member benefit. If you are an IASP member, please log in using your IASP credentials, and register for this webinar for free.
  • If you are a nonmember and would like to access the webinar, the fee is USD $25. Please click “Add to Cart” to pay the fee and register. You will be asked to create a nonmember IASP account. If interested in joining IASP as a member, information on joining is included in the “Become an IASP Member” tab above. Questions about IASP membership can be directed to

The IASP Pain Research Forum will host a seminar with Felipe A. Court, PhD, Universidad Mayor, Chile.

Here is an abstract of Dr. Court's talk:
Axonal degeneration is an active process involved in a variety of neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This non-apoptotic degenerative mechanism can cause permanent loss of function, so it represents a focus for neuroprotective strategies. Axonal degeneration is characterized by NAD+ depletion by SARM1 activation, increase in axonal ROS and Ca2+, and opening of the mitochondrial permeability transition pore. In addition, we have recently discovered that necroptosis activation is associated with axonal degeneration after a variety of stimuli. Importantly, defining the cascade for axonal degeneration might lead to the identification of potential targets for therapeutic intervention in a variety of conditions that lead to axonal loss.


  • Felipe Court, PhD

    Felipe Court, PhD, is Full Professor, and Director, Center for Integrative Biology, at Universidad Mayor, Chile. He studied biology in Chile working as an undergraduate in the lab of Dr. Jaime Alvarez on the topic of local protein synthesis in axons. He then moved to Europe and obtained an MSc and later a PhD at Edinburgh University, working in the labs of Dr. Richard Ribchester and Dr. Peter Brophy. Holding an EMBO postdoctoral fellowship, he moved to the lab of Dr. Laura Feltri in Milano, Italy. Dr. Court's research has been focused on studying the relationship between glial cells and neurons in different biological processes, including axonal degeneration, regeneration and intracellular transfer of cargoes. For this, his lab uses models of axonal degeneration and regeneration in vivo and in vitro, including models of optic and sciatic nerve regeneration and spinal cord injury.

Receive access to this IASP Pain Research Forum seminar with IASP membership. Become a member by clicking here.
October 26, 2021
Tue 12:00 PM EDT

Duration 1H 0M

This live web event has ended.

Event support