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IASP PRF Seminar: Axonal Degeneration as a Target for Therapeutic Strategies in Central Neurodegeneration and Peripheral Neuropathies

Description

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The IASP Pain Research Forum will host a seminar with Felipe A. Court, PhD, Universidad Mayor, Chile.

Here is an abstract of Dr. Court's talk:
Axonal degeneration is an active process involved in a variety of neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This non-apoptotic degenerative mechanism can cause permanent loss of function, so it represents a focus for neuroprotective strategies. Axonal degeneration is characterized by NAD+ depletion by SARM1 activation, increase in axonal ROS and Ca2+, and opening of the mitochondrial permeability transition pore. In addition, we have recently discovered that necroptosis activation is associated with axonal degeneration after a variety of stimuli. Importantly, defining the cascade for axonal degeneration might lead to the identification of potential targets for therapeutic intervention in a variety of conditions that lead to axonal loss.

Contributors

  • Felipe Court, PhD

    Felipe Court, PhD, is Full Professor, and Director, Center for Integrative Biology, at Universidad Mayor, Chile. He studied biology in Chile working as an undergraduate in the lab of Dr. Jaime Alvarez on the topic of local protein synthesis in axons. He then moved to Europe and obtained an MSc and later a PhD at Edinburgh University, working in the labs of Dr. Richard Ribchester and Dr. Peter Brophy. Holding an EMBO postdoctoral fellowship, he moved to the lab of Dr. Laura Feltri in Milano, Italy. Dr. Court's research has been focused on studying the relationship between glial cells and neurons in different biological processes, including axonal degeneration, regeneration and intracellular transfer of cargoes. For this, his lab uses models of axonal degeneration and regeneration in vivo and in vitro, including models of optic and sciatic nerve regeneration and spinal cord injury.

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October 26, 2021
Tue 12:00 PM EDT

Duration 1H 0M

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