Skip to main content

Episode 28: Efficacy and Safety of Minimally Invasive Surgery with Thrombolysis in Intracerebral Haemorrhage Evacuation (MISTIE III)

Loading audio, please wait...


Dr. Fawaz Al-Mufti is joined by Dr. Daniel Hanley and Dr. Issam Awad to discuss Dr. Hanley's recent article, "Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial."

The NCS Podcast is the official podcast of the Neurocritical Care Society. Our senior producer is Bonnie Rossow. Our host is Fawaz Almufti, and our production staff includes Ramani Balu, Michael Brogan, Joshua Levine, Sarah Stern-Nezer, Benjamin Miller, Starane Shepherd, and Chris Zammit. Our administrative staff include Becca Stickney, Sara Memmen, and Angel Gindele. Music by Mohan Kottapally.

This podcast is sponsored by the TTM Academy program at Penn Medicine, an educational initiative to improve care for patients following cardiac arrest and other neurocritical illness using targeted temperature management. This includes live CME workshops, an on-line video educational program, and a free podcast program. Find out more at


  • Daniel Hanley, MD

    Since 1996, Dr. Hanley has been a Professor of Neurology, Neurosurgery and Anesthesia/Critical Medicine at Johns Hopkins Medical Institutions. Since 1999, Dr. Hanley has also been Professor, School of Nursing, the Jeffrey and Harriett Legum Professor of Acute Care Neurology and Director of Brain Injury Outcomes Program at Johns Hopkins Medical Institutions. Dr. Hanley is a graduate of Williams College and Cornell University Medical College and has board certification in internal medicine, neurology and psychiatry. Dr. Hanley is a leading expert on multiple types of brain injury and has received more than 40 clinical and basic research grants, predominately from the National Institute of Health and the FDA Orphan drugs program. He has published more than 190 articles in peer-reviewed journals, has received the Alexander Humboldt Research Prize for his accomplishments in brain injury research and has extensive clinical trials experience in that field. His trainees are directors of over 20 brain intensive care units across the United States. Dr. Hanley is on the board of directors of the National Stroke Association and has developed nationally recognized education and training programs for that organization. He has significant experience in the areas of clinical trials design, organization and interpretation: drug development: device development and regulatory compliance. He is the principle investigator for the NIH sponsored MISTIE and CLEAR trials investigating minimally invasive neurosurgical techniques to treat hemorrhagic stroke.

  • Issam Awad, MSc, MD

    Dr. Awad is widely recognized for career long contributions and special skills in Neurovascular Surgery. He has made numerous scientific discoveries including the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of vascular malformations of the brain, and technical developments in neurovascular and epilepsy surgery. His research has been funded by the National Institutes of Health since 1998, focusing currently on molecular mechanisms of cerebral vascular malformations and their biomarkers, and minimally invasive techniques for treating hemorrhagic stroke. Awad’s innovations are changing neurosurgical practice throughout the world, and he has trained scores of neurosurgeons, some of whom are leaders of neurosurgical departments in a number of countries. His scholarly work has been cited more than 35,000 times (H Index 84). Dr. Awad has served in leadership roles at several national professional societies, he has been inducted in the Association of American Physicians, and he currently serves on the U.S. National Advisory Council for Neurological Disorders and Stroke.