The articles included in this month’s issue of Research Ethics Digest offer new discussion of challenging and controversial topics related to research ethics, including discussion of the 3R’s in animal research, informed consent in biobanking, the ethical considerations behind therapeutic appropriation, the FDA’s draft guidance on electronic informed consent, self-consent in HIV research for gender and sexual minority youth, and further topics.

Articles included:

• What’s Wrong with Human/Nonhuman Chimera Research?
• Lapse in Institutional Animal Care and Use Committee Continuing Reviews
• Ethics of Modeling of Cerebral Ischemia in Small Animals
• Animal Research, the 3Rs, and the "Internet of Things": Opportunities and Oversight in International Pharmaceutical Development
• Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes
• Content Analysis of Informed Consent for Whole Genome Sequencing Offered by Direct-to-Consumer Genetic Testing Companies
• Improving Biobank Consent Comprehension: A National Randomized Survey to Assess the Effect of a Simplified Form and Review/Retest Intervention
• Biobanking and the Abandonment of Informed Consent: An Ethical Imperative
• Healing Without Waging War: Beyond Military Metaphors in Medicine and HIV Cure Research
• Clearing Complexity from the Common Rule NPRM
• Research in Disaster Settings: A Systematic Qualitative Review of Ethical Guidelines
• Can an Ethics Officer Role Reduce Delays in Research Ethics Approval? A Mixed-Method Evaluation of an Improvement Project
• Problems with Ethical Approval and How to Fix Them: Lessons from Three Trials in Rheumatoid Arthritis
• Therapeutic Appropriation: A New Concept in the Ethics of Clinical Research
• Truth in Science Publishing: A Personal Perspective
• A Tool Kit to Enhance the Informed Consent Process for Community-Engaged Pediatric Research
• Research Involving Adults Lacking Capacity To Consent: The Impact Of Research Regulation On ‘Evidence Biased’ Medicine
• A Randomized Study of Multimedia Informational Aids for Research on Medical Practices: Implications for Informed Consent
• Liability and Informed Consent in the Context of Shared Decision Making
• Digitizing Consent: The Food and Drug Administration’s Draft Guidance on Electronic Informed Consent
• Linguistic Strategies for Improving Informed Consent in Clinical Trials Among Low Health Literacy Patients
• Ensuring Respect for Human Research Participants: Institutional Review Boards and Sharing Results from Research
• When are Clinical Trials Beneficial for Study Patients and Future Patients? A Factorial Vignette-Based Survey of Institutional Review Board Members
• Institutional Review Boards Evaluate Good Science: Template for Success
• Good and Bad Research Collaborations: Researchers’ Views on Science and Ethics in Global Health Research
• "It’s All About Trust": Reflections of Researchers on the Complexity and Controversy Surrounding Biobanking in South Africa
• National Ethics Guidance in Sub-Saharan Africa on the Collection and Use of Human Biological Specimens: A Systematic Review
• Bioethics Training Programmes for Africa: Evaluating Professional and Bioethics-Related Achievements of African Trainees after a Decade of Fogarty NIH Investment
• Self-Consent for HIV Prevention Research Involving Sexual and Gender Minority Youth: Reducing Barriers through Evidence-Based Ethics.
• Teens and Research: Should We Enroll Adolescents in Trials of Deep Brain Stimulation for Anorexia Nervosa?
• Advancing HIV Research with Pregnant Women: Navigating Challenges and Opportunities
• A Randomized Study of a Method for Optimizing Adolescent Assent to Biomedical Research

PRIM&R’s Research Ethics Digest, an electronic publication, delivers timely and relevant abstracts and full-text articles from a wide array of scholarly journals to the inboxes of PRIM&R members every two months. Articles featured in Research Ethics Digest highlight new research and scholarship related to ethics and regulation that affect—and potentially enhance—daily work.

The Research Ethics Digest Self-Study Program allows PRIM&R members to earn continuing education credits, which can be applied toward their Certified IRB Professional (CIP®) credential, Certified Professional in IACUC Administration (CPIA®) credential recertification, or other professional credentials they may hold.