This month’s issue of Research Ethics Digest includes articles on the most challenging topics relevant to research ethics, including the need for econometric research in laboratory animal operations; ethical and regulatory challenges associated with the National Patient-Centered Clinical Research Network; the role of informed consent in the era of personalized medicine; and much more.

Articles included:

• Applying the ARRIVE Guidelines to an In Vivo Database
• Opening Up Animal Research and Science–Society Relations? A Thematic Analysis of Transparency Discourses in the United Kingdom
• The Need for Econometric Research in Laboratory Animal Operations
• The Three Rs of Animal Research: What They Mean for the Institutional Animal Care and Use Committee and Why
• Anticipated Ethics and Regulatory Challenges in PCORnet: The National Patient-Centered Clinical Research Network
• Can Informed Consent to Research be Adapted to Risk?
• Ethical Challenges in Early-Phase Pediatric Research for Life-Limiting Illness
• Research Partnerships Between High and Low-Income Countries: Are International Partnerships Always a Good Thing?
• The Ethics of Big Data: Current and Foreseeable Issues in Biomedical Contexts
• Drifting Away from Informed Consent in the Era of Personalized Medicine
• Ethical Responsibilities and Perceptions of Stakeholders of Genetic Research Involving Racial/Ethnic Minority Participants
• Start Me Up: Ways to Encourage Sharing of Genomic Information with Research Participants
• The Development of a Preference-Setting Model for the Return of Individual Genomic Research Results
• Understandings of Genomic Research in Developing Countries: A Qualitative Study of the Views of MalariaGEN Participants in Mali
• Drifting Away from Informed Consent in the Era of Personalized Medicine
• Ethical Responsibilities and Perceptions of Stakeholders of Genetic Research Involving Racial/Ethnic Minority Participants
• Start Me Up: Ways to Encourage Sharing of Genomic Information with Research Participants
• The Development of a Preference-Setting Model for the Return of Individual Genomic Research Results
• Understandings of Genomic Research in Developing Countries: A Qualitative Study of the Views of MalariaGEN Participants in Mali
• Evaluating Community Engagement in Global Health Research: The Need for Metrics
• Exploring the Concept of Vulnerability in the Work of the US Presidential Commission for the Study of Bioethical Issues
• Making up ‘Vulnerable’ People: Human Subjects and the Subjective Experience of Medical Experiment
• Proposed Guidelines for the Protection of Vulnerable Subjects in Clinical Trials: Protections for Decisionally Impaired Subjects

PRIM&R’s Research Ethics Digest, an electronic publication, delivers timely and relevant abstracts and full-text articles from a wide array of scholarly journals to the inboxes of PRIM&R members every two months. Articles featured in Research Ethics Digest highlight new research and scholarship related to ethics and regulation that affect—and potentially enhance—daily work.

The Research Ethics Digest Self-Study Program allows PRIM&R members to earn continuing education credits, which can be applied toward their Certified IRB Professional (CIP®) credential, Certified Professional in IACUC Administration (CPIA®) credential recertification, or other professional credentials they may hold.