This conference content is available complimentary to PRIM&R members.
Research may move from the laboratory to human subjects or from animal
models to human subjects. Animal-to-human research/clinical trials is
neither a one-way street nor is it a straight line/sequential; there
might be many back and forths. What clinicians see in practice may end
up back in the animal research realm to better understand underlying
mechanisms so as to develop preventions and cures. Is the information
from the animal research limited in time in its applicability? Are there
reasons to revisit research in animals at different stages when it is
used in humans or triggered by certain events. Is the characterization
of an adverse event different for the two species? Should it be? And,
how do we define the relevance of adverse events in animals to adverse
events in humans?
Learning Objectives:
- Review how research in animals informs further research on the same agent in humans
- Consider how adverse events in animals translates specifically to adverse events in humans
- Learn how to identify when previous research on animals may need to be revisited in light of events occurring as the research in humans progresses