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The Roadmap for Next Generation Oncology: The Contribution of Tridimensional Models-Recording

The challenge in tissue engineering applied to the development of 3D cancer models is the possibility to mimic the complexity of a specific microenvironment, with the biological, chemical and mechanical properties. It is widely accepted that the cancer microenvironment is the result of cell-cell and cell-extra cellular matrix interactions. Drug discovery invests resources and money in testing compounds and drugs with a 5% success rate. This failure is mainly due to the use of inadequate tools to predict the efficacy and safety of the drugs.

From a side flat 2D cell cultures and to the other side animal models fail to detect the side-effects of drugs, mimic the metastatic progression or the interaction between cancer and immune system. There is room for new technologies and platforms that can overcome also ethical and regulatory issues. However, many models are proposed but there is still an urgent need to validate predictive platform. 3D models such as spheroids and organoids could improve the drug development and testing, because they can help in understanding the physiopathology of the tumor microenvironment. They can be coupled with microfluidics devices or embedded in biomaterials. These systems can copycat the features of the tumor microenvironment and the interaction among different cells or cells and extracellular matrix.

The presentation is a journey in the state-of-the-art of 3D in vitro culture system, to understand where we stand and what are the future trends in the topics.

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