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SC36 - Inherited Gynecologic Cancer Syndromes - Pathologically and Clinically Based Risk Assessment and Genetic Counseling: What every practicing pathologist should know



Evaluated by: 
Laura W. Lamps, M.D., UAMS Health, M.D., FIAC, July 8, 2016
Original release date: July 7, 2016
Access to this course expires on:July 7, 2019
CME/SAMs 2.75

Course Description
This course provides registrants an overview of inherited gynecologic cancer syndromes with emphasis on BRCA-associated and Lynch syndromes. Specific topics include: biological and clinical underpinnings of BRCA1 and BRCA2 dysfunction and PARP function; current models of serous carcinogenesis; how to assess for hereditary ovarian cancer risk- importance of genetic counseling and the use of pathology and family history as risk assessment tools; ovarian cancer risk reduction strategies, including chemoprevention, surveillance and risk reducing surgery; proper grossing techniques for risk reducing (i.e. prophylactic) salpingo-oophorectomy specimens; criteria for the diagnosis of intraepithelial serous carcinoma of the fallopian tube and the distinction of this lesion from mimics; strategies for diagnosing both grossly visibly and clinically inapparent lesions in salpingo-oophorectomy specimens; current concepts of the morphologic phenotype of BRCA1 associated ovarian, tubal and peritoneal carcinoma; biological and clinical attributes of BRCA1 inactivated ovarian, tubal and peritoneal carcinoma, including an introduction to the rationale for targeted therapy; biological and clinical underpinnings of Lynch syndrome in endometrial and ovarian cancer; rationale behind assessment for hereditary cancer risk in patients with endometrial cancer; risk assessment for Lynch Syndrome genetic counseling, family history and pathology; techniques used to determine Lynch syndrome risk in patients with endometrial cancer, including morphologic, immunohistochemical and molecular diagnostic examination; algorithms used to determine Lynch syndrome risk; ethical and regulatory issues concerning screening patients for cancer predisposition syndromes. The genetic basis, clinical presentation and morphologic features of tumors associated with other, less common gynecologic cancer syndromes will also be covered: Peutz Jeghers; Cowden; Hereditary leiomyomatosis/renal cell carcinoma; Tuberous sclerosis; Ataxia telangiectasia.

Target Audience
Practicing academic and community pathologists, and pathologists-in-training

Learning Objectives
Upon completion of this educational activity, learners will be able to:

  • Recognize key histologic features in inherited gynecologic malignancies
  • Provide and discuss advantages and disadvantages of suggested laboratory tests and testing algorithms for inherited gynecologic malignancies
  • Understand the role of the pathologist in the implementation and evaluation of screening modalities and risk reducing procedures for these patients.

The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this enduring material for a maximum of 2.75 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The USCAP is approved by the American Board of Pathology (ABP) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABP requirements for Maintenance of Certification (MOC). Registrants must take and pass the post-test in order to claim SAMs credit.

Physicians can earn a maximum of 2.75 SAM credit hours.

The faculty, committee members, and staff who are in position to control the content of this activity are required to disclose to USCAP and to learners any relevant financial relationship(s) of the individual or spouse/partner that have occurred within the last 12 months with any commercial interest(s) whose products or services are related to the CME content. USCAP has reviewed all disclosures and resolved or managed all identified conflicts of interest, as applicable.

The following faculty reported no relevant financial relationships: Teri Longacre, M.D., Angela G. Arnold, M.S. and Robert Soslow, M.D.

USCAP staff associated with the development of content for this activity reported no relevant financial relationships.

To earn CME and SAM credit, all learners must take a content-based exam and achieve a minimum score of 80%. If learners do not achieve a passing score of 80%, they have the option to retake the exam. After you pass the test and complete the evaluation, your certificate of completion will be available to view and print by clicking here.


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