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SC17 Part 1 - Trapdoors in Testicular Pathology

Daniel M. Berney, FRCPath, Barts and The London School of Medicine and Dentistry, London, England and Muhammed Idrees, MD, Indiana University Medical Center, Indianapolis, IN

The rarity and complexity of testicular tumors present unique challenges for pathologists. The spectrum of morphologic variation in testicular tumors is tremendous and poses a great challenge, especially in general surgical pathology practice because of limited exposure to these rare tumors. Even as specialists, genitourinary pathologists may deal with only a handful of cases on an annual basis. Correct diagnosis is the key in clinical management of many of these tumors where decisions of administration of chemotherapy are often made on pathological appearances. Additionally, inherited disorders may be associated with unique morphologic variants, making it extremely challenging to cater the management in terms of lifelong commitment for the patients and the clinicians. This course will present information directly relevant to diagnostic surgical pathologists and will be based on evidence published in peer-reviewed journals. Both Indiana University School of Medicine and St Bartholomews Hospital have international and long-established reputations in testicular pathology, with unparalleled collections of tumors to share with the faculty. Material from these cases will be utilized in providing examples of diagnostically difficult cases along with a detailed discussion of diagnostic dilemmas surrounding the specific entities including variants of seminoma, solid yolk sac tumor, dermoid cyst, cystic trophoblastic disease, variant Sertoli cell tumors, gonadoblastoma, rete carcinoma, and angiomyofibroblastoma. The case presentations will cover histopathological features, differential diagnosis, adjuvant diagnostic techniques, patient management, and recent advances in the understanding of pathogenesis. Virtual slides and still images, along with histories, will be posted on the USCAP website for review by preregistrants prior to the meeting. A syllabus reviewing diagnostic features and differential diagnosis, and providing a comprehensive reference list will be available online prior the meeting. All course registrants will also receive web access to the PowerPoint presented at the USCAP Annual Meeting along with the text portion of the syllabus.

Upon completion of this educational activity, participants should be able to:
  1. Accurately diagnose and identify the spectrum of morphologic variation in testicular tumors
  2. Be familiar with the prognostic and treatment implications of their diagnoses
  3. Have insight into recent advances in the understanding of the pathogenesis of these tumors.

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