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Acute Leukemia


Evaluated by: David B. Kaminsky, M.D., FIAC, August 8, 2017
Original release date: August 8, 2017
Access to this course expires on: April 8, 2020
CME/SAMs 1.25

Faculty: Daniel A. Arber, M.D.

Narrative Description:
This course will focus in the distinctive morphologic features of acute leukemia specimens and how they correlate with immunophenotypic and molecular genetic changes. The emphasis will be on the morphologic changes in acute myeloid leukemia and their correlation with diagnostic categories in the 2016 WHO classification of hematopoietic tumors as well as discussion of recent changes to the WHO classification.

Intended Audience:
Practicing academic and community pathologists, pathologists-in-training, hematopathologists.

Topics Covered:
  • Acute myeloid leukemia (AML) with recurrent genetic abnormalities
  • Role of gene mutations and dysplastic cellular changes in AML
  • Myeloid proliferations of Down syndrome
Learning Objectives:
  • Recognize characteristic morphologic features associated with specific genetic abnormalities in acute myeloid leukemia
  • Understand the differential diagnosis of megakaryocytic proliferations in childhood
  • Understand the major gene mutations that impact diagnosis and prognosis in AML


To earn CME and SAM credit, all learners must take a content-based exam and achieve a minimum score of 80%. If learners do not achieve a passing score of 80%, they have the option to retake the exam. After you pass the test and complete the evaluation, your certificate of completion will be available to view and print by clicking here.