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Myeloproliferative Neoplasms

Evaluated by:
David B. Kaminsky, M.D., FIAC, August 8, 2017
Original release date: August 8, 2017
Access to this course expires on: April 8, 2020
CME/SAMs 1.5

Faculty: Attilio Orazi M.D., FRCPath. (Engl.)

Narrative Description:
A specific diagnosis is necessary to guide clinical decision. Unfortunately, often the bone marrow diagnoses rendered in cases of myeloproliferative neoplasms (MPN) are descriptive and therefore inadequate to guide clinical decisions. Many pathologists have limited experience with these neoplastic conditions due to their relative rarity and/or the lack of adequate clinical or laboratory information. This presentation reviews the key features which are characteristically associated with the main subtypes of MPN and how they can be used to resolve common diagnostic issues including the separation of MPN from other myeloid neoplasms (e.g. myelodysplastic/myeloproliferative neoplasms). The recently updated WHO 2016 diagnostic criteria are fully reviewed. An overview of the important issue of early phase disease as well as of disease progression in MPN are also provided.

Topics Covered:
  • Myeloproliferative neoplasms
  • Myelodysplastic/myeloproliferative neoplasms
  • Identification of early and late phases of polycythemia vera and primary myelofibrosis and their disease progression manifestations
  • Key hematologic features of the above
Learning Objectives:
  • Become familiar with the current diagnostic criteria for MPN
  • Learn how to achieve a careful integration of morphology with clinical and biologic data (e.g., cytogenetics and molecular genetics) to produce a clinically useful integrated report
  • Be familiar with early phases of disease
To earn CME and SAM credit, all learners must take a content-based exam and achieve a minimum score of 80%. If learners do not achieve a passing score of 80%, they have the option to retake the exam. After you pass the test and complete the evaluation, your certificate of completion will be available to view and print by clicking here.