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Splenic Proliferations

Evaluated by: David B. Kaminsky, M.D., FIAC, August 8, 2017
Original release date: August 8, 2017
Access to this course expires on: April 8, 2020

Faculty: Attilio Orazi M.D., FRCPath. (Engl.)

Narrative Description:

Spleens are examined by general surgical pathologists and hematopathologists, often lacking adequate expertise. This is largely a consequence of poor knowledge concerning how to approach splenic pathology in a diagnostic setting, compounded by the rarity of many of the conditions affecting the spleen and the limited occurrence of diagnostic or therapeutic splenectomy. The presentation covers the differential diagnosis of splenomegalic lymphoid neoplasms, stressing how a careful integration of morphologic and immunophenotyopic features can be used to achieve a specific diagnosis. Because splenic lymphoid proliferations have frequent manifestations in the bone marrow and peripheral blood, those important disease components are also reviewed. In addition, the main histologic features seen in a wide range of non-lymphoid neoplasms as well as in vascular and pseudotumorral splenic lesions are covered.

Target Audience:
Practicing academic and community pathologists, pathologists-in-training, hematopathologists

Topics Covered:
  • Splenic lymphoid neoplasms
  • Splenic myeloid metaplasia
  • Splenic pseudotumoral and vascular lesions
  • Key hematopathologic features of the above
Learning Objectives:
  • Learn a practical approach to splenic neoplastic and pseudotumoral lesions
  • Learn how to achieve a careful integration of morphology with clinical and biologic data (e.g., cytogenetics and molecular genetics) to produce a clinically useful integrated report
  • Apply an effective diagnostic strategy focused on key ancillary tests of truly diagnostic value
To earn CME and SAM credit, all learners must take a content-based exam and achieve a minimum score of 80%. If learners do not achieve a passing score of 80%, they have the option to retake the exam. After you pass the test and complete the evaluation, your certificate of completion will be available to view and print by clicking here.