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S02 Biomechanics of the eye

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Description

Optic nerve head (ONH) biomechanics have been hypothesized to play an important role in the pathogenesis of glaucoma, and this symposium will present the current state of research on the biomechanics of the ONH and peripapillary tissues, as well as the clinical implications of ocular biomechanics in glaucoma. A comprehensive framework will be presented that introduces ONH and peripapillary scleral biomechanics in the contexts of: 1) macro-scale ONH tissue and cerebrospinal fluid compartment anatomy; 2) three-dimensional lamina cribrosa microarchitecture; 3) the biomechanics and IOP-induced remodeling of the sclera and lamina cribrosa; and 4) aging and racial variations in scleral stiffness.

Contributors

  • J. Crawford Downs, PhD

    Affiliation: Professor of Ophthalmology, Biomedical Engineering, and Computer and Information Science University of Alabama at Birmingham Birmingham, Alabama, USA

    Areas of Interest: Dr. Downs is a career research scientist who developed continuous intraocular pressure telemetry in nonhuman primates. His focus is on using continuous IOP data, 3D image analysis, and engineering tools to elucidate the roles of scleral and optic nerve head biomechanics in glaucoma. He is NIH-funded in ONH biomechanics and IOP telemetry, and is working in both the nonhuman primate model of glaucoma and human donor eyes, with a focus on determining basis for increased age- and race-related susceptibility to glaucoma.

    Leadership Positions: Vice-chair of Basic Science Research, UAB Department of Ophthalmology; Director, UAB School of Medicine Center for Ocular Biomechanics and Biotransport (COBB);

    Special Honors: Co-author on the paper that won the AIGS award for best basic science paper in glaucoma research 2004. Dr. Downs has published more than 8 book chapters and 48 peer-reviewed papers in the field, and serves as a frequent grant reviewer for NIH, European Governments, and several private foundations.

  • Jost B. Jonas

    Prof Jonas is currently Professor of Ophthalmology of the Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg in Germany.

    Prof. Jonas has research interests in the intravitreal application of medication as treatment of intraocular edematous, proliferative and neovascular diseases; the intravitreal cell-based (drug) therapy; the homologous intravitreal bone-marrow transplantation; the retinal microglial cell system; the femtosecond laser assisted surgery of the cornea; the contact lens associated ophthalmodynamometry for measurement of the retinal arterial and venous blood pressure; the morphologic diagnosis of optic nerve diseases including the glaucomas; population-based studies (Beijing Eye Study; Central India Eye and Medical Study; Beijing Eye Childhood Study; Beijing Eye Public Health Care Project);

    Prof. Jonas is on the Editorial Board of several European ophthalmic journals.

    For his research, he became member of the German Academy of Science Leopoldina, the Glaucoma Society of the International Congress of Ophthalmology, the Macula Society, and the Retina Society. He is Honorary Member of the Asia-Pacific Vitreoretinal Society and Fellow of the Association of Research in Vision and Ophthalmology ARVO. He has received the Glaucoma Award of the German Ophthalmologic Society, the Junior and Senior Award of the American Academy of Ophthalmology, the Senior Clinical Scientist Award of the World Glaucoma Association, the Prof. Robert-Ritch Glaucoma Award, and the International Gold Awards of the Chinese Ophthalmologic Society.

  • Vincent Libertiaux

    Affiliation: Research Associate at the Center for Ocular Biomechanics and Biotransport, University of Alabama at Birmingham

    Research interests: Ocular biomechanics, image processing, glaucoma

  • Massimo A Fazio, PhD

    Affiliation: Research Associate at School of Medicine, University of Alabama at Birmingham, United States.

    Areas of interest: Biomechanics of ocular tissues and its interaction with glaucoma etiology and aging of the eye, interferometric deformation measurements in biological tissues, in-vivo strain biomechanics, image processing, multi-level hierarchical statistical analysis.

    Leadership positions: Member of the Advisory Network of the Optical Society of America, member of the Association for Research in Vision and Ophthalmology.

  • Rafael Grytz, PhD

    Affiliation: Assistant Professor, Department of Ophthalmology, University of Alabama at Birmingham.

    Research interest: Biomechanical mechanisms in glaucoma, myopia, keratoconus; growth and remodeling of eye tissues; predictive computer simulations.

    Leadership Positions: Organizer and co-chair of 8 minisymposiums mainly on biomechanics of living tissues; first-author of 10 peer reviewed articles and 1 book chapter; invited lecturer and guest speaker at Stanford University, University of Pittsburgh, Osaka University, Devers Eye Institute, Technical University of Braunschweig, Ruhr-University Bochum, Meeting of the International Society for Eye Research (ISER), Association for Research in Vision and Ophthalmology (ARVO), ‘Deutsche Ophthalmologische Gesellschaft’ (DOG) Congress.

    Special honours: ‘Deutscher Studienpreis’ 2nd price (2009); Travel fellowships by International Society for Eye Research (ISER) (2012), ‘Deutsche Ophthalmologische Gesellschaft’ (DOG) (2012), US Association of Computational Mechanics (USACM) (2012), German Research Council (DFG) (2003, 2006); research awards by Ruhr University Bochum (2010, 2003).

  • Claude F Burgoyne, MD

    Claude F Burgoyne, MD is Van Buskirk Chair for Ophthalmic Research and Director of the Optic Nerve Head Research Laboratory at the Devers Eye Institute in Portland, Oregon. His laboratory studies the effects of aging and experimental glaucoma on the tissues of the monkey optic nerve head within post-mortem 3D histomorphometric reconstructions. It is now translating these techniques to in vivo human optic nerve head imaging using Spectral Domain Optical Coherence Tomography.

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