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S04 Novel diagnostic targets in glaucoma

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Description

The ability to diagnose glaucoma earlier and with greater precision remains an important goal in the management of the disease. The symposium explores novel diagnostic targets, including multifocal pupil perimetry; new approaches to the imaging of the optic nerve, laminar cribrosa and retina; imaging of the retinal vasculature and measurement of ocular blood flow; imaging of changes in the brain; and biomarkers associated with glial activation. The speakers will discuss how these various approaches might lead to improved targets for the early diagnosis of glaucoma.

Contributors

  • John G. Flanagan PhD, MCOptom

    Affiliation: Professor at both the Department of Ophthalmology and Vision Science, University of Toronto and the School of Optometry and Vision Science, University of Waterloo, Ontario, Canada. Head of Glaucoma Research, Toronto Western Research Institute. Senior Scientist at the Toronto Western Hospital, University Health Network.

    Research Interests: Basic mechanisms of human glaucoma, particularly glial cell activation; neuroprotection; ocular imaging; clinical psychophysics; 24-hour IOP; ocular blood flow and studies of vascular reactivity.

    Leadership Positions: Founding member of the Optometric Glaucoma Society, was Program Chair from 2002 to 2007, President from 2007 to 2012 and currently Executive Vice President. In 2008 he was appointed Chair of the Clinical Research Ethics Committee at the University of Waterloo. Author of 10 book chapters and 4 books, he has supervised 32 graduate students and has authored over 140 peer reviewed publications.

    Special Honors: Awards include Certificate of Merit for Research Excellence, Glaucoma Research Society of Canada; Claire Bobier Lecture, University of Waterloo; Springer Lecture, University of Alabama; Dario Lorenzetti Lecture, McGill University Glenn A. Fry Award from the American Academy of Optometry; Outstanding Performance Award, University of Waterloo; and the Mel Silverman Mentorship Award from the Institute of Medical Sciences, University of Toronto.

  • Christopher Leung, MD, MB ChB, MSc, BMedSc, FHKAM, FCOphth

    Christopher Leung, MD, MB ChB, MSc, BMedSc, FHKAM, FCOphth(HK)

    Affiliation: Professor, Head – Graduate Division, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

    Areas of interest: Glaucoma Progression Analysis, Ocular Biomechanics, Primary Angle Closure, Optic Disc and Retinal Nerve Fiber Layer Imaging, Retinal Ganglion Cell Imaging, Neuroprotection.

    Leadership positions: Associate Advisory Board Member (Co-Chair Clinician Scientist Committee) - World Glaucoma Association; Editorial Board Member - Ophthalmic Epidemiology, International Glaucoma Review, Journal of Ophthalmology, Recent Patents on Medical Imaging, Ophthalmic Surgery, Laser and Imaging, Ocular Surgery News – Asia Pacific Academy of Ophthalmology, Asia Pacific Journal of Ophthalmology; Member – Glaucoma Research Society; Scientific Coordinator – World Ophthalmology Congress 2008, Asia Pacific Academy of Ophthalmology Congress 2009 – 2012..

    Special honors: Stuart Brown Lecturer (University of California, San Diego) 2013, Asia Pacific Glaucoma Society Young Investigator Award 2012, American Academy of Ophthalmology (AAO) Secretariat Award 2012, World Glaucoma Congress Science Award Young Clinician Scientist Award 2011, Asia Pacific Joint Glaucoma Congress Young Scientist Award 2010, ARVO Alcon Clinician-Scientist Research Award 2010, Asia Pacific Academy of Ophthalmology (APAO) Nakajima Award 2010, APAO Achievement Award 2010, World Glaucoma Congress Science Award The Promise 2009, AAO Achievement Award 2008, ARVO Travel Grant Award 2007, Schanzlin Research Award 2007, Croucher Foundation Fellowship Award 2006, National Best Paper on Prevention of Blindness World Ophthalmology Congress 2006, Action for Vision Outstanding Researcher of the Year 2005, Action for Vision Young Researcher of the Year 2004.

  • Linda M. Zangwill, PhD

    Affiliation: Professor of Ophthalmology
    Director, Diagnostic Imaging Laboratory, Hamilton Glaucoma Center
    Department of Ophthalmology, University of California, San Diego, CA.

    Areas of Interest: Improving techniques for detection and monitoring of glaucomatous structural and functional damage and change over time; identifying risk factors for the development and progression of glaucoma.

    Leadership Positions: Journal of Glaucoma Editorial Board Member, International Perimetric Society Board Member; Glaucoma Research Society; UC San Diego The Sam and Rose Stein Institute for Research on Aging; Faculty Chair: UC San Diego Chancellor’s Advisory Committee on the Status of Women; International Glaucoma Review (IGR) Editorial Board Member; UCSD Women’s Leadership Alliance Executive Committee. Principal Investigator, National Eye Institute funded: “Diagnostic Innovations in Glaucoma Study (DIGS): Structural Assessment”; “African Descent and Glaucoma Evaluation Study (ADAGES) II: Glaucoma Progression”;‘OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmoscopy”

    Honors: One of ten ‘Best papers on glaucoma published in the scientific literature’, Association of International Glaucoma Societies (WGA) 2001, 2005; American Academy of Ophthalmology Achievement Award; Association for Research in Vision and Ophthalmology Silver Fellow Award.

  • Ted Maddess

    Ted graduated from the University of British Columbia in 1980 in biology, where his research interests included the diversity of waveguide properties of photoreceptor cells in the animal kingdom.
    In 1981 he obtained a scholarship to do a PhD at the Australian National University with Adrian Horridge and Simon Laughlin on insect vision. They put him onto recording from neurons sensitive to image motion. Ted discovered a form of frequency dependent gain control in these cells. Towards the end of his PhD Ted moved to Geoff Henry’s lab and showed that same effect operated in visual cortical neurons.

    Ted then obtained a Canadian MRC Fellowship to work with Geoff. Geoff was an ex-optometrist who initiated Ted’s interest in glaucoma.  Soon afterwards Ted filed a patent for detecting glaucoma using a different gain control related property, the frequency doubling illusion. Welch Allyn Inc funded his research on the FD method between 1990 and 1994. After several smaller experiments a proof of concept was obtained in a study, facilitated by Ivan Goldberg, of 320 subjects tested 7 times. The project was then passed to the able hands of Chris Johnson for final development.

    Ted has also worked on motion adaption in eye movements, illusions of scale and brightness, and texture discrimination. He began working with Andrew James on new multifocal methods in 1992, and their discoveries have now advanced the multifocal pupillographic objective perimetry (mfPOP) method.

    Ted is currently Director if the ARC Centre of Excellence in Vision Science at the ANU.

  • Tae-Woo Kim

    Title and Affiliation: Director, Associate professor, Department of Opthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine.

    Research Interest: Techniques for diagnosing glaucoma and glaucoma progression, Optic nerve head biomechanics, Relationship between myopia and glaucoma, Disc hemorrhage, Parapapillary Atrophy. Leadership positions: Director of international affairs of the Korean Glaucoma Society.

    Special honors: Taejoon Academy Award from the Korean Ophthalmological Society (2002), Yeonam Academy Award from the Korean Glaucoma Society (2007), Best Paper Award in the American Academy of Ophthalmology meeting (2010), Research Recognition Award from the World Glaucoma Association (2011).

  • Dr. David Huang, MD, PhD

    Dr. David Huang, MD, PhD is the Weeks Professor of Ophthalmic Research and a professor of ophthalmology and biomedical engineering at the Oregon Health & Science University (OHSU). Dr. Huang earned the MD degree from Harvard and a PhD in Medical Engineering and Medical Physics from MIT. He received ophthalmology residency training at the Doheny Eye Institute/USC and fellowship training in cornea, external disease and refractive surgery at Emory University School of Medicine. Prior to joining OHSU, Dr. Huang had been on the faculty of the Cleveland Clinic and the University of Southern California.
    Dr. Huang is a co-inventor of optical coherence tomography (OCT), an imaging technology that has been applied to the measurement of eye structures with unprecedented precision. His seminal article on optical coherence tomography, published in Science in 1991, has been cited more than 7000 times. He has 15 issued patents and 15 pending patents in the areas of OCT, mobile health testing, tissue engineering and corneal laser surgery. He has been the principal investigator of 4 National Institutes of Health research grants totaling over $20 million. He has published more than 110 peer-reviewed articles and edited 4 books. Dr. Huang has received the Champalimaud Vision Award, the Friedenwald Award from the Association for Research in Vision & Ophthalmology, Senior Achievement Award from the American Academy of Ophthalmology. Dr. Huang leads the Center for Ophthalmic Optics and Lasers (www.COOLLab.net ) and the Advanced Imaging in Glaucoma Study ( www.AIGStudy.net ).

  • Stuart L. Graham, MBBS, PhD, MS, FRANZCO

    Affiliation: Professor and Head of Dept, Ophthalmology and Visual Science. ASAM, Macquarie University, Sydney, Australia, and Visiting Professor, Sydney University/Save Sight Institute

    Areas of Interest: Glaucoma subspecialist ophthalmologist with background in electrophysiology and clinical research in glaucoma and optic neuritis. Developed objective perimetry using the multifocal VEP.

    Special interests include vascular changes in glaucoma, neurodegeneration mechanisms and new MRI techniques.

  • Jeremy M. Sivak, PhD

    Dr. Sivak holds the Glaucoma Research Chair at the Toronto Western Hospital Research Institute, and is Assistant Professor at the University of Toronto. His work studies the molecular pathways directing tissue damage and repair responses in the eye, and he has published and lectured on a range of related research in high-impact scientific journals and international meetings. He received his graduate training at the New England Medical Center/Tufts University in Boston, MA, followed by postdoctoral research at the Wellcome Trust funded Gurdon Institute, at the University of Cambridge, UK. Prior to his appointment in Toronto, Dr. Sivak was a project leader at Novartis, a leading pharmaceutical company, where he ran ophthalmic drug discovery projects to identify molecular targets and drug candidates to treat a variety of eye diseases, as well as investigations in ocular drug delivery. His current research program is aimed at deciphering the basic mechanisms resulting in retinal and optic nerve damage in patients with glaucoma, and developing new strategies for treatment and prevention of their vision loss. Toward this goal, he has received support from several funding agencies, including the Glaucoma Research Society of Canada (GRSC), the Canadian National Institute for the Blind (CNIB), and the Canadian Institutes of Health Research (CIHR), as well as the Toronto General and Western Hospital Foundation.

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