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S13 Advances in Glaucoma Genetics

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Description

Recent research have led to the successful identification of genes and genetic risk factors for a number of types of glaucoma including primary open angle glaucoma, primary angle closure glaucoma, congenital glaucoma and pseudoexfoliation. Other studies have investigated the genes underlying quantitative traits that are important in glaucoma such as central corneal thickness and optic disc traits. These discoveries are critical toward the future development of gene based screening and novel therapeutic approaches based on molecular genetics. The International Glaucoma Genetics Consortium has been formed in the last few years to increase research and collaboration in this area. 

In this session, experts will present an overview of recent advances in glaucoma genetics as well as suggest directions for future research, in order for attendees to update their knowledge of this rapidly advancing field.

Contributors

  • Professor Tin Aung

    MBBS (Singapore), FRCS(Ed), FRCOphth (UK), MMed (Ophth) (Singapore), FAM (Singapore), PhD (London) Professor Tin Aung is Senior Consultant and Head, Glaucoma Service, Singapore National Eye Centre (SNEC); Deputy Director, Singapore Eye Research Institute (SERI); and Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore (NUS). Prof Aung is a clinician-scientist and leads the Glaucoma Research Group at SNEC/SERI. His main research interests are angle closure glaucoma and the molecular genetics of eye diseases. With >300 publications, he has been an invited lecturer to >100 international conferences. Prof Aung has been awarded >US$10 million in competitive research grant funding and has received numerous awards including the Singapore NMRC-Clinician Scientist Awards in 2005 and 2008, the President’s Science Award in 2009 and the Nakajima and De Campo Awards from the Asia Pacific Academy of Ophthalmology. Prof Aung is a member of the Editorial Boards of Ophthalmology, Journal of Glaucoma, Eye, Graefe’s Archive for Clinical and Experimental Ophthalmology, Asia Pacific Journal of Ophthalmology and 5 other journals. Prof Aung is currently Associate Executive Vice President of the World Glaucoma Association and a Board member of the Asia-Pacific Glaucoma Society and the Asian Angle Closure Glaucoma Club. In Singapore, he is the current President of the College of Ophthalmologists of Singapore and immediate past President of the Singapore Society of Ophthalmology.

  • Professor David Mackey

    Lions Eye Instittue, University of Western Australia

    Genetics of glaucoma

    President of the International Society for Genetic Eye Disease and Retinoblastoma
    Board member Ophthalmic Research Institute of Australia
    Member of the American Academy of Ophthalmology Basic Clinical Sceince Course Textbook 2 editorial Committtee
    Member Australian National Health and Medical Research Council, Human Genetics Advisory Committee
    Chair Western Australia branch of the Royal Australian and New Zealand College of Ophthalmologists

    Awards
    RANZCO Excellence in Training Award 2012
    Asia-Pacific Academy of Ophthalmology Distinguished Service Award 2011
    Alcon Research Institute 2010 Awardee
    University Foundation Graduate Award, University of Tasmania 2009
    Prize for Best Poster RANZCO 2007.
    Prize for the best scientific presentation at the European Glaucoma Society Meeting London June 2000.
    Kabi Pharmacia award for the best scientific paper Royal Australian College of Ophthalmologists Meeting Hobart 1993.
    Founders cup for the best scientific paper at the 1993 Oxford Ophthalmological Conference.

    Named Lecture
    Gillies Lecture, Australian and New Zealand Stabismus Society 2012
    Gerard Crock Lecture, Centre of Eye Research Australia, Melbourne, 2009
    Ian Constable Lecture, University of Western Australia, Perth, 2008
    Gillies Lecture, Australian and New Zealand Glaucoma Interest Group, Melbourne, 2008
    Norman McAlister Gregg Lecture Royal Australian and New Zealand College of Ophthalmologists Annual Meeting, Hobart, 2005
    Council Lecture for the Royal Australian College of Ophthalmologists Annual Meeting, Melbourne, 1999
    Fred Hollows Lecture at the Australian Basic Visual Science Meeting, Canberra, 1998.
    Patricia Lance Lecture of the Australian Orthoptic Association Conference, Melbourne, 1995.

  • Prin Rojanapongpun, MD

    Affiliation: Associate Professor and Chairman of the Department of Ophthalmology at Chulalongkorn University and Hospital. Chief glaucoma consultant to the Queen Sirikit National Institute of Child Health, Ministry of public health. He is also a consultant at Bumrungrad International and Sukumvit Hospital Eye Care Center in Bangkok, Thailand.

    Research interest: Angle closure glaucoma, the epidemiology and diagnosis of glaucoma, medical and surgical management of patients with glaucoma, and coexisting cataract-glaucoma.

    Leadership positions:
    -President, Asian Angle Closure Glaucoma Club (AACGC), Executive board of Asia Pacific Glaucoma Society (APGS), Immediate past president of SEAGIG
    -Council and Chairman of Advocacy committee, Asia Pacific Academy of Ophthalmology (APAO)
    -Executive Board, Asia Pacific Association of Cataract and Refractive Surgeons (APACRS)
    -Scientific and Executive board, The Royal College of Ophthalmologists of Thailand

    Special honours: International Awardee from ASCRS, APACRS, APAO, Red Cross society.

  • Janey L. Wiggs, MD, PhD

    Affiliation: Paul Austin Chandler Associate Professor at Harvard Medical School and the Massachusetts Eye and Ear Infirmary; Associate Chief for Clinical Research in Ophthalmology at the Massachusetts Eye and Ear Infirmary;
    Director the Genetics Eye Disease Diagnostic Laboratory at the Massachusetts Eye and Ear Infirmary.

    Areas of Interest: Discovery and characterization of genetic factors that contribute to inherited forms of glaucoma.

    Leadership Positions: US co-chair of the US-INDO joint working group (NEI); member of the NEI eyeGENE consortium; Member of the editorial boards of Investigative Ophthalmology and Visual Science (IOVS), Archives of Ophthalmology (Section Editor from Molecular Genetics), Molecular Vision, and the Journal of Glaucoma. Member of the scientific advisory board for the Glaucoma Research Foundation and is a past member of the National Advisory Council of the National Eye Institute.

    Awards: ARVO silver and gold fellow.

  • Jamie Craig, MD, PhD

    Affiliation: Associate professor, Department of Ophthalmology, Glaucoma, Flinders University, South Australia

    Areas of Interest: genetic susceptibility to glaucoma blindness, pseudoexfoliation syndrome, diabetic retinopathy and cataract

    Leadership Position: As an NHMRC Practitioner Fellow he divides his time between clinical care of glaucoma patients and running a research laboratory. He established the Australian and New Zealand Registry of Advanced Glaucoma in 2007, which has recruited a repository of over 1200 cases of glaucoma blindness, and 800 secondary glaucoma cases. His laboratory conducts Genome Wide Association Studies and gene discovery projects in monogenic traits

  • Alex Hewitt

    Alex Hewitt, Senior Research Fellow, Head of Clinical Genetics Unit

    Affiliation: Centre for Eye Research Australia, University of Melbourne

    Areas of Interest: Alex’s main research interests lie in the molecular mechanisms of glaucoma. He has been involved with work relating to the identification of genes and risk variants associated with primary open-angle glaucoma and myopia, as well as quantitative traits such as central corneal thickness, optic nerve size and the retinal microvascular circulation.

    Special Honors: Alex is currently supported by a Peter Doherty Australian National Health and Medical Research Council Biomedical Fellowship. In 2012 he was the Novartis Research Fellow at the Lions Eye Institute and was awarded a WA Tall Poppy Award from the Australian Institute of Policy & Science.

  • Michael A Hauser, PhD

    Affiliation: Professor of Medicine, Division of Medical Genetics; Professor of Ophthalmology, Duke University Eye Center; Professor of Molecular Genetics and Microbiology, Duke University.

    Areas of Interest: The genetics of macular degeneration. The genetics of primary open angle glaucoma. Co-PI of the NEI glaucoma Human Genetics collaboration (NEIGHBOR) genome wide association study of glaucoma in US Caucasian populations. Co-PI of the International Consortium of African Ancestry Research in glaucoma (ICAARE-glaucoma). Currently performing whole exome sequencing to identify novel mutations causing primary congenital glaucoma.

    Leadership positions: Director of the Duke Center for Human Genetics Biobank, 2007-present. Chair of Admissions, Duke University Program in Genetics and Genomics, 2009. Director of Graduate Studies, Duke University Program in Genetics and Genomics, 2010-2012. Executive Committee of the Graduate Faculty, Duke University Graduate School, 2012-present.

  • Manir Ali, PhD

    Affiliation: Section of Ophthalmology and Neuroscience, Leeds Institute of Biomedical & Clinical Sciences, St. James’s University Hospital, University of Leeds, UK

    Research Interests: All aspects of glaucoma genetics, molecular genetics of inherited eye disease particularly in isolated populations or families where there is consanguinity.

    Leadership Positions: Group Leader in the Section of Ophthalmology and Neuroscience, University of Leeds; Reviewer for various ophthalmic and genetic journals; Have co-authored numerous publications in international peer-reviewed journals; Panel Member for the Royal Society Newton International Travel Fellowships.

  • Murray Fingeret, OD

    Affiliation: Chief of the Optometry Section, Brooklyn/St. Albans Campus, Department of Veterans Administration New York Harbor Health Care System Brooklyn, NY. Clinical Professor at the State University of New York, College of Optometry.

    Leadership Positions: Fellow of the American Academy of Optometry, Board of Directors of the Glaucoma Foundation, Founding member and past-president of the Optometric Glaucoma Society. Editorial board member of the Journal of Glaucoma, International Glaucoma Review, Glaucoma Today, Primary Care Optometry News, Optometry Times and Review of Optometry.

    Special Honors: Recipient of the 2008 Distinguished Service Award Optometric Glaucoma Society; 2005 Carel C. Koch Memorial Medal from the American Academy of Optometry; 1999 AMSUS Federal Service Optometrist of the Year award. 2010 Optometric Glaucoma Society Distinguished Service Award

    Research Interest: Perimetry, Imaging, New Instrument and Normative Database Development

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