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Pathophysiology and New Molecular Targets of Bone Marrow Failure

Interview with Dr. Matthew Walter from Washington University in St. Louis - Recorded March 2016
Questions answered include:

  1. What are the genetics that underline MDS?
  2. What kind of mutations of the blood cells cause MDS?
  3. What pathways can be targeted with therapy?
  4. What are splicing gene mutations?
  5. Are there new treatments and clinical trials that target patients with splicing gene mutations and/or an overactive TGF beta pathway?
  6. What are the critical genes that are mutated in MDS that set the cancer off?