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Extracellular Vesicles and Membrane-mimetics for Tissue Regeneration

2021 IADR/AADR/CADR General Session

The 99th General Session & Exhibition of the IADR was to be held in conjunction with the 50th Annual Meeting of the American Association for Dental Research and the 45th Annual Meeting of the Canadian Association for Dental Research, from July 21-24, 2021 as a Virtual Experience.

The recordings in this library from the meeting are a selection of the science that was to be presented as part of the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers, the IADR Academy and symposia from a collection of scientific groups and networks.

This session can be purchased as part of the full meeting recordings within the product bundles

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Session Description 
Cell-based therapies have demonstrated promising efficacy in clinical studies, but are impeded by several challenges. For instance, transplantation of living replicative cells, such as the stem cells, poses potential risks of tumor formation and occlusions in distal microvasculature. Furthermore, cell-based medicine is limited by operational and logistical challenges to maintain the optimal cell viability and potency. Recently, extracellular vesicles (EVs) and specialized cellular components, such as plasma membrane and mitochondrion, have been explored as “cell-free” alternatives in various therapeutic applications.

EVs are bi-lipid membrane vesicles secreted by most cells and microorganisms (e.g., bacteria) contain rich cargos of nucleic acids, lipids and proteins. EVs act as important mediators of intercellular communication, as they possess the ability to transfer bioactive cargo components to elicit diverse biological responses in recipient cells.

Plasma membranes that can be isolated from various cell types have also emerged as a promising tool in regenerative medicine. These bioactive membranes offer a unique nanotechnology bio-interface that is highly amenable for site-targeting, drug delivery, imaging and other modifications.

This symposium focuses on the latest advances in EVs derived from stem cells and periodontal microbes, and membrane-mimetics for applications in tissue regeneration. Speakers from different backgrounds including stem cell biology, material science and tissue engineering will discuss about the current standing point, and the questions and problems to be solved for the future goals in the field of EVs and membrane-mimetics. New insights to the highly innovative technologies on EVs and membrane-mimetics gathered in the discussion will shape the future development of next-generation therapeutics.

Learning Objectives
  • This symposium will provide the state-of-the-art knowledge on the application of extracellular vesicles isolated from stem cells and periodontal microbiota as well as membrane mimetics in tissue regeneration.
  • This symposium will gather scientists from different backgrounds, including cell biology, material science and bioengineering.
  • This multidisciplinary approach is expected to encourage the attendee/learner to develop a multidisciplinary and integrative mind and attitude towards the development of new solutions for dental and medical problems.
Presentation Date
July 22, 2021

Wei Seong Toh
Shipin Zhang
Akihiro Okamoto
Emilio Hara

Sponsoring Groups/Networks
Periodontal Research, Stem Cell Biology Research

CE Credits
1.5 Contact Hours

Financial Interest Disclosure:

Not eligible for individual purchase must purchase as part of a meeting bundle.