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Integrative Single-cell Omics: Opportunities for Oral and Craniofacial Research



2021 IADR/AADR/CADR General Session

The 99th General Session & Exhibition of the IADR was to be held in conjunction with the 50th Annual Meeting of the American Association for Dental Research and the 45th Annual Meeting of the Canadian Association for Dental Research, from July 21-24, 2021 as a Virtual Experience.

The recordings in this library from the meeting are a selection of the science that was to be presented as part of the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers, the IADR Academy and symposia from a collection of scientific groups and networks.

This session can be purchased as part of the full meeting recordings within the product bundles





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Session Description 
Studying all the cells in humans is an enormous endeavor—current estimates suggest human bodies are made of at least 35 trillion cells. Among the spaces in the body, the oral and craniofacial tissues are incredibly diverse, including tongue to teeth and gums to glands. Each is supported by epithelia, cartilage, bone, ligaments, muscles, adipose tissue, blood and lymphatic vessels, and nerves; and all of these tissues are harmoniously integrated into the vital functions of communication, feeding, breathing, defense, sensing, and early digestion. Oral and craniofacial tissues are affected in many disorders and diseases that can decrease quality of life and cause deleterious psychosocial issues, emphasizing the need for effective, precise, and aesthetic strategies for the regeneration of craniofacial tissues. New approaches in single-cell omics are already allowing for comprehensive and integrated cell atlases to understand the cell types that support these niches in health and uncover which cell types and networks are affected in disease. This level of cell annotation and integration will be critical for understanding oral and craniofacial diseases across the lifespan. In tandem, due to the growing body of literature displaying interconnected roles for oral and systemic health, findings from this network will be critical to future meta-analyses with other tissue and organ atlases for precision diagnostics and treatments. This session will feature uses of these new single-cell approaches to resolve our collective biology at a higher resolution and will also outline future directions for mapping the oral and craniofacial tissues across the lifespan.

   Learning Objectives
  • To gain new knowledge about how single-cell omics are being used to discover common and rare cell types in the human oral & craniofacial tissues in health.
  • To learn about how to uniquely apply single-cell omics approaches to common disease states of the oral tissues to identify cell types and pathways that may be novel targets for precision treatments in the future.
  • To describe how the collective effort of oral health researchers and providers across disciplines will be required to achieve the first draft of the human oral and craniofacial cell atlas.
Presentation Date
July 22, 2021

Presenters
Drake Williams - Human Cell Atlas of the Oral Mucosal Barrier in Health and Inflammatory Disease
Kevin Byrd - Single-Cell Immune Profiling-From Oral-gut Axis to COVID-19
Jan Krivanek - Dental Cell Type Atlas: Applications and Perspectives
Ana Caetano - Construction of a Human Gingiva Cell Atlas in Health and Disease

Sponsoring Groups/Networks
Craniofacial Biology Research, Periodontal Research, Pulp Biology & Regeneration Research, Salivary Research

CE Credits
1.5 Contact Hours

Financial Interest Disclosure:
In the last year KMB has been a Scientific Advisor at Arcato Laboratories, Inc. and Coordinator at the Human Cell Atlas.

Not eligible for individual purchase must purchase as part of a meeting bundle.