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Stem Cell Approaches for Understanding Dental-Oral-Craniofacial (DOC) Biology



2021 IADR/AADR/CADR General Session

The 99th General Session & Exhibition of the IADR was to be held in conjunction with the 50th Annual Meeting of the American Association for Dental Research and the 45th Annual Meeting of the Canadian Association for Dental Research, from July 21-24, 2021 as a Virtual Experience.

The recordings in this library from the meeting are a selection of the science that was to be presented as part of the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers, the IADR Academy and symposia from a collection of scientific groups and networks.

This session can be purchased as part of the full meeting recordings within the product bundles





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Session Description 
Embryonic development relies on precise execution of differentiation programs carried out by pluripotent stem cells that have the ability to form every cell in the body. During gastrulation, these cells become further specified into endodermal, mesodermal, ectodermal, and neural crest derivations. Dental-oral-craniofacial (DOC) tissues such as teeth, facial bones and salivary glands are generated by the neural crest in a process that often requires input from adjacent non-neural ectoderm, and bones of the cranial vault and facial muscles derive from mesoderm. However, the molecular mechanisms underlying the formation of DOC tissues have remained less well understood. This symposium will describe recent advances in our understanding of differentiation into DOC tissues by highlighting diverse approaches and novel technologies. In particular, through proteomics and ATAC seq, new insight is emerging on the mechanisms by which pluripotent stem cells commit to a neural crest fate and the role of ubiquitylation in this process. Novel live cell imaging and spatial genomic analysis is shedding light on how neural crest cells gain and maintain their stemness. By using single-cell analysis, lineage trajectories of stem and progenitor cells are being used to map out development of salivary glands. Furthermore, directed differentiation following embryonic pathways of specification is being applied to generate neural crest-specific and mesoderm-specific osteoprogenitor populations with signature transcriptomic patterns. These studies provide the opportunity to better identify and characterize DOC stems cells, to determine the pathogenetic roles that they play in DOC diseases, and to use them to restore normal structure and function.

Learning Objectives
  • The learner will acquire a better understanding of what stem cells are, how they are defined, and mechanisms that underlie DOC stem cell maintenance and differentiation.
  • The learner will learn about new approaches for the study of DOC stem cells, and how these new approaches can be used to shed light on the development, structure and function of DOC tissues.
  • The learner will gain an appreciation of the role of DOC stem cells in health and disease.
Presentation Date
July 24, 2021

Presenters
Achim Werner - Ubiquitin-Dependent Cell-Fate Decision During Neural Crest Development
Laura Kerosuo - Understanding Neural Crest Stemness
Belinda Hauser - ScRNAseq Analysis of Salivary Gland Development: Characterizing Intercalated Duct (ID) Cells
Fahad Kidwai - Human Induced Pluripotent Stem Cell-Derived Lineage Specific Osteoprogenitors: an in Vitro Model to Study the Pathological Process of Rare Craniofacial Diseases

Sponsoring Groups/Networks
Stem Cell Biology Research

CE Credits
1.5 Contact Hours

Financial Interest Disclosure:
None

Not eligible for individual purchase must purchase as part of a meeting bundle.