Organ-on-a-Chip systems combined with Stem Cell Biology is creating a paradigm shift in the understanding of cell-cell, cell-matrix, host-microbiome, and host-environment interactions that have immense applications in basic research and drug discovery.
Organ-on-a-chip systems leverage on recent advances in microfluidic and microfabrication technologies to create miniaturized devices containing hollow microchannels and microchambers that support the continuous supply of nutrients and drainage of metabolic wastes, application of shear stress, and model micro/nano features. These systems also enable the application of test substances (oral-care products and biomaterials) in a close to clinical use context.
These features of microfluidic organ-on-chip systems have enabled the reconstruction of the native physiology of human tissues and the complex interactions between cells, matrix, microbiome and/or external environment. This has led to an exponential increase in the application of organ-on-chip systems across various organ systems in the body. In the last 5 years, these next-generation tools have gained traction in dental and craniofacial research. Some examples include skin-on-chip, tooth-on-chip, oral mucosa-on-chip, salivary tissue-on-chip and bone-on-chip. This symposium aims to present the applications of these next-generation microfluidic and organ-on-chip technologies in dental and craniofacial research.
Organ-on-a-chip systems leverage on recent advances in microfluidic and microfabrication technologies to create miniaturized devices containing hollow microchannels and microchambers that support the continuous supply of nutrients and drainage of metabolic wastes, application of shear stress, and model micro/nano features. These systems also enable the application of test substances (oral-care products and biomaterials) in a close to clinical use context.
These features of microfluidic organ-on-chip systems have enabled the reconstruction of the native physiology of human tissues and the complex interactions between cells, matrix, microbiome and/or external environment. This has led to an exponential increase in the application of organ-on-chip systems across various organ systems in the body. In the last 5 years, these next-generation tools have gained traction in dental and craniofacial research. Some examples include skin-on-chip, tooth-on-chip, oral mucosa-on-chip, salivary tissue-on-chip and bone-on-chip. This symposium aims to present the applications of these next-generation microfluidic and organ-on-chip technologies in dental and craniofacial research.