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A Translational Population Pharmacokinetic Model for the Prediction of Linear Pharmacokinetics of Monoclonal Antibodies in Humans using Cynomolgus Monkey and hFcRn Tg32 Mice

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Contributors

  • Alison Betts, Ph.D.

    Dr. Betts is a member of the Translational Modeling & Simulation Group in the Biomedicine Design department at Pfizer, where she is translational modeling and simulation (M&S) lead supporting the Oncology Research Unit. In this role she leads a team responsible for using M&S strategies to answer mechanistic questions, validate targets, select optimal compounds, translate preclinical data to the clinic and predict efficacious dose/regimen. Her main area of work is on novel biotherapeutic modalities in immune-oncology including checkpoint inhibitor mAbs, bi-specific T-cell retargeting molecules, targeted nanoparticles and drug conjugates for treatment of cancer. Prior to these roles, Dr. Betts worked across many Research Units at Pfizer (including Pain, Cardiovascular and Antibacterial) to establish modeling and translational pharmacology to drive projects forward.

May 30, 2019
Thu 12:30 PM EDT

Duration 1H 30M

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