Description
About this webinar
Oral sustained release dosage forms offer many benefits in
comparison with immediate release dosage forms including improved treatment
effectiveness, reduced side effects, and convenient dosing. The majority of
oral sustained-release formulations are large tablets and capsules that must
not be crushed, causing difficulty in administration for pediatric patients and
patients with dysphagia (swallowing difficulties). Suspension of microparticles
in an easy-to-swallow liquid is one approach to develop sustained release
formulations for these patients. This webinar provides a review of
microencapsulation technologies that could be used in producing sustained-release
microparticles for liquid suspensions, including spray drying, spray congealing,
emulsion solvent evaporation and ionic resin complexation. The advantages and
challenges of the existing technologies are compared. A recent development in a
novel processing technology that improves the efficiency of fluidized bed
coating to produce sustained release microparticles is discussed with case
studies that apply the technology for a range of APIs with different
physio-chemical properties. Examples of incorporating sustained-release
microparticles in oral liquid suspensions for single-dose or multi-dose use are
provided. Other patient-centric approaches that could apply sustained-release
microparticles for pediatric and geriatric patients are discussed including
dispersible tablets and ODTs.
Learning Objectives
- Identify the opportunities and challenges in developing oral liquid sustained release suspension for pediatric and geriatric patients
- Describe existing microencapsulation technologies that enable the development of oral sustained release liquids
- Examine recent advancement in fluidized bed coating process for scalable production of sustained-release microparticles
- Explore patient-centric approaches in developing oral sustained release formulations